5638-70-0

Usage

Uses

Used in Pharmaceutical Industry:
[1,3]OXAZINANE-2,6-DIONE is used as a reagent in organic synthesis for the creation of pharmaceutical compounds. Its unique structure allows it to be a key component in the development of various drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, [1,3]OXAZINANE-2,6-DIONE is utilized as a building block for the synthesis of pesticides. Its incorporation into these products aids in the enhancement of crop protection strategies and contributes to the development of more effective and targeted agrochemicals.
Used in Biological Research:
[1,3]OXAZINANE-2,6-DIONE has been studied for its potential biological activity, including its anticancer properties. Researchers are exploring its capacity to target and inhibit the growth of cancer cells, making it a promising candidate for further investigation in oncology.
Additionally, it has shown antibacterial properties, indicating its potential use in the development of new antimicrobial agents to combat bacterial infections. This dual potential in both cancer and bacterial research underscores the compound's versatility and importance in the field of medicinal chemistry.

InChI:InChI=1/C4H5NO3/c6-3-1-2-5-4(7)8-3/h1-2H2,(H,5,7)

Upstream product

• 2304-94-1 3-(benzyloxycarbonylamino)propanoic acid 
• 75-09-2 dichloromethane 
• 7789-60-8 phosphorus tribromide 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 107-95-9 3-amino propanoic acid 
• 16690-93-0 sodium β-alaninate 
• 3303-84-2 3-(tert-butyloxycarbonylamino)propionic acid 

Downstream Products

• 40331-75-7 3-(2-nitro-phenylsulfanyl)-[1,3]oxazinane-2,6-dione 

Relevant academic research and scientific papers

Preparation method of beta-alanyl-L-histidine

The invention relates to the technical field of polypeptide synthesis, in particular to a preparation method of beta-alanyl-L-histidine. The preparation method of the beta-alanyl-L-histidine provided by the invention comprises the following steps: carrying out a reaction on beta-alanine and solid triphosgene to prepare 1, 3-oxazinane-2, 6-diketone, and then carrying out ring opening to prepare the beta-alanyl-L-histidine. The route of the method is shortened to two steps, the raw material conversion rate is high, the post-treatment is simple, and the purity of the obtained product is high.

METHOD OF SYNTHESIZING N-CARBOXYANHYDRIDE USING FLOW REACTOR

PROBLEM TO BE SOLVED: To provide a synthesis method that allows high-yield continuous production of a compound of interest in synthesis and production of N-carboxyanhydride (NCA) and the like using a flow reactor. SOLUTION: In a synthesis method using a flow reactor 100, a basic solution adjusted in advance to a pH of 7-14 becomes acidic with a pH of 0-7, or an acidic solution adjusted in advance to a pH of 0-7 becomes basic with a pH of 7-14, within 60 seconds after the start of mixture of at least two ingredient solutions. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2020,JPOandINPIT

Single-Step, Rapid, and Mild Synthesis of β-Amino Acid N-Carboxy Anhydrides Using Micro-Flow Technology

β-Amino acid N-carboxy anhydrides (β-NCAs) are rarely used in the synthesis of β-peptides, which is due mainly to the poor availability of these potentially useful substrates. Herein, we describe the heretofore challenging synthesis of β-NCAs via a single

Simultaneous assembly of the β-lactam and thiazole moiety by a new multicomponent reaction

A novel multicomponent reaction of β-aminothiocarboxylic acids, aldehydes, and 3-dimethylamino-2-isocyanoacylate is described. During the course of this reaction two heterocyclic moieties, a thiazole and a β-lactam ring, are formed simultaneously and under mild conditions. The increase in molecular complexity here is dramatic as 2 C-N, 2 C-S and 1 C-C bonds are formed in a new 'one-pot' multicomponent reaction.

Urethane N-carboxyanhydrides from β-amino acids

A general method has been developed for the synthesis of N-tert-butyloxycarbonyl N-carboxyanhydrides from β-amino acids using Vilsmeier complex. These β-UNCA are stable, and the reactivity with different nucleophiles (alcohol, amine, lithium enolate) was studied.