56401-06-0

Basic information

• Product Name: 7-Benzyldaidzein
• Synonyms: 7-Benzyldaidzein
• CAS NO: 56401-06-0
• Molecular Formula: C₂₂H₁₆O₄
• Molecular Weight: 345.36798
• Mol File: 56401-06-0.mol

Chemical Properties

• Appearance: /
• Solubility: DCM
• CAS DataBase Reference: 7-Benzyldaidzein(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Benzyldaidzein(56401-06-0)
• EPA Substance Registry System: 7-Benzyldaidzein(56401-06-0)

Safety Data

• Hazardous Substances Data: 56401-06-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
7-Benzyldaidzein is used as an intermediate in the synthesis of Daizein (D103500) for [application reason]. Daizein, being the inactive analog of Genistein (G350000), plays a crucial role in the development of pharmaceutical compounds that target various health conditions.
Used in Chemical Synthesis:
7-Benzyldaidzein is used as a key compound in the chemical synthesis of other flavonoids and related compounds. Its unique structure allows for further modification and functionalization, leading to the development of new molecules with potential applications in various industries, including pharmaceuticals, cosmetics, and agriculture.

Upstream product

• 586407-35-4 1-(4-benzyloxy-2-hydroxyphenyl)-3-[4-(methoxymethoxy)phenyl]prop-2-en-1-one 

Downstream Products

• 1365659-36-4 3-cyano-6-(4-hydroxyphenyl)-7-(2-hydroxyl-4-benzyloxyphenyl)pyrazolo[1,5-a]pyrimidine 
• 1456626-82-6 3-cyano-6-(4-benzyloxy-2-hydroxyphenyl)-5-(4-hydroxyphenyl)pyridin-2(1H)-one 
• 1427272-71-6 3-cyano-6-(4-benzyloxy-2-hydroxylphenyl)-5-(4-hydroxyphenyl)-pyridine-2(1H)-thione 
• 486-66-8 daidzein 

Relevant articles and documents

Structural requirement of isoflavonones for the inhibitory activity of interleukin-5

Sophoricoside isolated from Sophora japonica is a glycoside of isoflavonone as an inhibitor of interleukin (IL)-5. To identify structural requirements of this isoflavonone for its inhibitory activity against IL-5, isoflavonones, isoflavanones, and their glycosides were prepared and their inhibitory activity was tested against IL-5. Among them, 5-benzyloxy-3-(4-hydroxyphenyl)chromen-4-one (4b, 87.9% inhibition at 50 μM, IC50=15.3 μM) shows the most potent activity, comparable with that of sophoricoside. The important structural requirements of these isoflavonone analogs exhibiting the inhibitory activity against IL-5 were recognized as (1) planarity of chromen-4-one ring, (2) existence of phenolic hydroxyl at 4-position of B ring, and (3) introduction of benzyloxy at 5-position, which may act as a bulky group for occupying hydrophobic pocket in putative binding site. However the glucopyranosyl moiety of sophoricoside is not an essential motif for the activity.