586407-35-4

Upstream product

• 29682-12-0 1-[4-(benzyloxy)-2-hydroxyphenyl]ethanone 
• 6515-21-5 4-methoxymethoxy-benzaldehyde 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 100-39-0 benzyl bromide 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 56401-06-0 7-benzyloxy-3-(4-hydroxy-phenyl)-chromen-4-one 

Relevant academic research and scientific papers

Structural requirement of isoflavonones for the inhibitory activity of interleukin-5

Sophoricoside isolated from Sophora japonica is a glycoside of isoflavonone as an inhibitor of interleukin (IL)-5. To identify structural requirements of this isoflavonone for its inhibitory activity against IL-5, isoflavonones, isoflavanones, and their glycosides were prepared and their inhibitory activity was tested against IL-5. Among them, 5-benzyloxy-3-(4-hydroxyphenyl)chromen-4-one (4b, 87.9% inhibition at 50 μM, IC50=15.3 μM) shows the most potent activity, comparable with that of sophoricoside. The important structural requirements of these isoflavonone analogs exhibiting the inhibitory activity against IL-5 were recognized as (1) planarity of chromen-4-one ring, (2) existence of phenolic hydroxyl at 4-position of B ring, and (3) introduction of benzyloxy at 5-position, which may act as a bulky group for occupying hydrophobic pocket in putative binding site. However the glucopyranosyl moiety of sophoricoside is not an essential motif for the activity.