56413-64-0Relevant academic research and scientific papers
I2 mediated one-pot synthesis of 1,2,4-triazoles from amidines and imidates
Inturi, Surendra Babu,Kalita, Biswajit,Ahamed, A. Jafar
supporting information, p. 2227 - 2230 (2016/05/10)
A one-pot facile synthesis of 3,5-disubstituted-1H-1,2,4-triazole derivatives using I2/Cs2CO3 has been described. The method involves readily available inexpensive reagents and is applicable to a wide range of substrates.
Copper-catalyzed one-pot synthesis of 1,2,4-triazoles from nitriles and hydroxylamine
Xu, Hao,Ma, Shuang,Xu, Yuanqing,Bian, Longxiang,Ding, Tao,Fang, Xiaomin,Zhang, Wenkai,Ren, Yanrong
, p. 1789 - 1794 (2015/02/19)
A simple and efficient copper-catalyzed one-pot synthesis of substituted 1,2,4-triazoles through reactions of two nitriles with hydroxylamine has been developed. The protocol uses simple and readily available nitriles and hydroxylamine hydrochloride as th
Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates
Sudheendran, Kavitha,Schmidt, Dietmar,Frey, Wolfgang,Conrad, Jürgen,Beifuss, Uwe
, p. 1635 - 1645 (2014/02/14)
Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.
Copper-mediated sequential C-N and N-N bond formation: Facile synthesis of symmetrical 1,2,4-triazoles
Li, Zhonglian,Zhang, Zhiguo,Zhang, Wei,Liu, Qingfeng,Liu, Tongxin,Zhang, Guisheng
supporting information, p. 2735 - 2739 (2014/01/06)
Via a one-pot process, catalyzed by Cu(OAc)2, a series of 3,5-disubstituted 4H-1,2,4-triazoles was conveniently and efficiently synthesized by using low-toxicity, stable, readily available, inexpensive amidine hydrochloride. Georg Thieme Verlag Stuttgart New York.
Copper-catalyzed synthesis of 1,2,4-triazoles via sequential coupling and aerobic oxidative dehydrogenation of amidines
Xu, Hao,Jiang, Yuyang,Fu, Hua
supporting information, p. 125 - 129 (2013/02/23)
A convenient, efficient, and practical copper-catalyzed one-pot method for the synthesis of 1,2,4-triazoles has been developed via reactions of amidines. The procedure underwent sequential base-promoted intermolecular coupling (nucleophilic substitution) between two amidines and intramolecular aerobic oxidative dehydrogenation, and the inexpensive, convenient, and efficient method for the synthesis of 1,2,4-triazoles will attract much attention in academic and industrial research. Georg Thieme Verlag Stuttgart · New York.
An improved procedure for the deamination of symmetrical 3,5-disubstituted 4-amino-1,2,4-triazoles
Bentiss, Fouad,Lagrenee, Michel,Vezin, Herve,Bouanis, Marya,Mernari, Bouchaib
, p. 93 - 96 (2007/10/03)
A number of symmetrical 3,5-disubstituted-4H-1,2,4-triazoles have been synthesized in good yields by deamination of the corresponding 4-amino-1,2,4-triazoles via reductive diazotation of these amino compounds in the presence of hypophosphorous acid. Analy
Aryl s tetrazines with antiinflammatory activity
Lang Jr.,Johnson,Cohen,et al.
, p. 1404 - 1409 (2007/10/07)
Various aryl s tetrazines and benzyl s tetrazines displayed aspirin like activity when tested against carrageenan induced edema in the rat, uv induced erythema in guinea pigs, and adjuvant induced arthritis in rats. These agents also displayed analgesic activity in the mouse writhing and paw pain tests but also lowered the red blood cell count in normal healthy rats.
