56414-89-2

Basic information

• Product Name: H-PHE-PYRROLIDIDE
• Synonyms: H-PHE-PYRROLIDIDE;L-PHENYLALANINE PYRROLIDIDE;L-PHENYLALANINE PYRROLIDYL AMIDE;PHENYLALANINE-PYRROLIDIDE;(2S)-2-Amino-3-phenyl-1-(1-pyrrolidinyl)-1-propanone;(S)-1-(2-Amino-1-oxo-3-phenylpropyl)pyrrolidine;1-[(2S)-2-Amino-1-oxo-3-phenylpropyl]pyrrolidine;L-Phenylalanine pyrrolidide≥ 99% (TLC)
• CAS NO: 56414-89-2
• Molecular Formula: C₁₃H₁₈N₂O
• Molecular Weight: 218.29
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Chiral Reagents
• Mol File: 56414-89-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 397.4 °C at 760 mmHg
• Flash Point: 194.1 °C
• Appearance: /
• Density: 1.135 g/cm³
• Vapor Pressure: 1.59E-06mmHg at 25°C
• Refractive Index: 1.578
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• PKA: 7.90±0.33(Predicted)
• CAS DataBase Reference: H-PHE-PYRROLIDIDE(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-PYRROLIDIDE(56414-89-2)
• EPA Substance Registry System: H-PHE-PYRROLIDIDE(56414-89-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 56414-89-2(Hazardous Substances Data)

Usage

Chemical Properties

Brown Syrup

InChI:InChI=1/C13H18N2O/c14-12(10-11-6-2-1-3-7-11)13(16)15-8-4-5-9-15/h1-3,6-7,12H,4-5,8-10,14H2/t12-/m0/s1

Upstream product

• 123-75-1 pyrrolidine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 125139-05-1 N^α-(tert-butoxycarbonyl)-L-phenylalanine-N-pyrrolidinamide 
• 63-91-2 L-phenylalanine 

Downstream Products

• 449728-90-9 (S)-octanedioic acid (1-benzyl-2-oxo-2-pyrrolidin-1-yl-ethyl)amide trityloxy-amide 
• 1009093-32-6 C₄₈H₆₇N₅O₆ 
• 200267-75-0 (+)-(S)-2-amino-1-phenyl-3-(pyrrolidin-1-yl)propane 
• 144646-36-6 N²<(R)-2-benzamido-1,2,3,4-tetrahydro-7-methoxynaphthalene-2-carbonyl>-L-phenylalanine N¹,N¹-(tetramethylene)amide 
• 144646-36-6 N²<(S)-2-benzamido-1,2,3,4-tetrahydro-7-methoxynaphthalene-2-carbonyl>-L-phenylalanine N¹,N¹-(tetramethylene)amide 
• 144646-39-9 N²<(R)-1-benzamido-1,2,3,4-tetrahydronaphthalene-1-carbonyl>-L-phenylalanine N¹,N¹-(tetramethylene)amide 
• 144646-40-2 N²<(S)-1-benzamido-1,2,3,4-tetrahydronaphthalene-1-carbonyl>-L-phenylalanine N¹,N¹-(tetramethylene)amide 

Relevant articles and documents

Protecting-Group-Free Amidation of Amino Acids using Lewis Acid Catalysts

Amidation of unprotected amino acids has been investigated using a variety of ‘classical“ coupling reagents, stoichiometric or catalytic group(IV) metal salts, and boron Lewis acids. The scope of the reaction was explored through the attempted synthesis of amides derived from twenty natural, and several unnatural, amino acids, as well as a wide selection of primary and secondary amines. The study also examines the synthesis of medicinally relevant compounds, and the scalability of this direct amidation approach. Finally, we provide insight into the chemoselectivity observed in these reactions.

Chiral primary-tertiary diamine catalysts derived from natural amino acids for syn-aldol reactions of hydroxy ketones

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Design of an organocatalyst for the enantioselective Diels-Alder reaction with α-acyloxyacroleins

We have realized the first enantioselective organocatalytic Diels-Alder reaction between α-substituted acroleins, such as α-acyloxyacroleins, and not only cyclic but also acyclic dienes. α-Acyloxyacroleins are useful as synthetic equivalents of α-haloacro