56431-01-7

Upstream product

• 728-86-9 phenyl[4-(trifluoromethyl)phenyl]methanone 
• 925-90-6 ethylmagnesium bromide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 93-55-0 1-phenyl-propan-1-one 
• 711-33-1 4-trifluoromethyl propiophenone 
• 100-58-3 phenylmagnesium bromide 

Downstream Products

• 86043-00-7 1-Phenyl-1-(p-trifluormethylphenyl)-propen 

Relevant academic research and scientific papers

Iron-catalysed 1,2-aryl migration of tertiary azides

1,2-Aryl migration of α,α-diaryl tertiary azides was achieved by using the catalytic system of FeCl2/N-heterocyclic carbene (NHC) SIPr·HCl. The reaction generated aniline products in good yields after one-pot reduction of the migration-resultant imines.

Interannular Proton Exchange and Fragmentation of Carbonyl-protonated Benzophenones

Benzophenones (a) initially protonated at the carbonyl group were prepared by electron-impact induced dissociation of 1,1-diphenylpropanols (compounds 1-5).These protonated ketones decompose in the ion source and the second field-free region of a reversed geometry mass spectrometer by proton migration to one of the phenyl groups and subsequent elimination of benzene.In the case of derivatives substituted by methoxy groups and trifluoromethyl groups, respectively, the proton migrates predominantly to the more basic benzene ring, resulting in the elimination of anisole in the former case and of benzene in the latter case.A study of protonated benzophenones labelled at the phenyl ring and at the carbonyl group shows that only a few interannular H/D exchange steps precede the fragmentation.This is observed not only for metastable ions in the magnetic sector instrument but also for ions of long lifetimes investigated by Fourier-transform-ion cyclotron resonance (FT-ICR) spectrometry.This is in contrast to the arene elimination from protonated 1,ω-diphenylalkanes and related polyphenylalkanes which fragment by complete positional exchange of all hydrogen atoms at the aromatic rings.The special behaviour of protonated benzophenones is attributed to a low barrier for the decomposition of a chemically activated arenium ion (b), which arises from the initial proton transfer.Once (b) is formed, it decomposes quickly without much interannular proton exchange.

Arylcyclopropane Photochemistry. Effects of Electron-Donating and Electron-Withdrawing Aromatic Substituents on the Photochemical Rearrangements of 1,1-Diarylcyclopropanes.

Irradiation of 1,1-diarylcyclopropanes 4a-g, having substituents X and Y at the para positions of the aromatic rings, afforded 1,1-diarylpropenes 5a-g and 1-arylindans 6a-f.The rate constants of these (singlet state) reactions, determined from the reactan

Alpha-substituted benzhydrol derivatives

The invention relates to new α-substituted benzhydrols and pharmaceutically acceptable acid addition salts or quaternary ammonium salts thereof with enzyme promoting or inhibiting effects;

α-Substituted benzhydrol derivatives and a process for the preparation thereof

A compound of the formula: STR1 wherein Z is ethyl or vinyl, R1 and R2 are hydrogen, lower alkyl, lower alkenyl or trihalomethyl, R3 and R4 are hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, and R5 is lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl, or phenyl with the proviso that where R1, R2, R3 and R4 each is hydrogen, R5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof is disclosed as effective in the regulation of the liver microsomal enzyme system.