56432-20-3

Usage

Uses

Used in Pharmaceutical Industry:
3-(2-Hydroxynaphthalen-1-yl)benzaldehyde is used as an intermediate in the synthesis of pharmaceuticals for its ability to participate in various chemical reactions, contributing to the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, 3-(2-Hydroxynaphthalen-1-yl)benzaldehyde is used as a key building block for creating other organic compounds, owing to its reactive functional groups and structural versatility.
Used in Biological Research:
3-(2-Hydroxynaphthalen-1-yl)benzaldehyde is utilized in biological research as a compound with potential biological activities, making it a subject of study for its possible applications in medicine and other biological fields.

Upstream product

• 85-46-1 1-Naphthalenesulfonyl chloride 
• 87199-16-4 3-Formylphenylboronic acid 
• 7029-32-5 dinaphthalen-1-ylzinc 
• 75148-49-1 3-bromobenzaldehyde diethylacetal 
• 3132-99-8 m-bromobenzoic aldehyde 
• 13922-41-3 1-Naphthylboronic acid 

Relevant academic research and scientific papers

NOVEL REXINOID COMPOUNDS AND METHODS OF USING REXINOID COMPOUNDS FOR TREATING METABOLIC DISORDERS AND CANCER

Novel rexinoid compounds are provided herein. Also provided herein are methods of using the compounds to treat disorders, such as metabolic disorders, diabetes, insulin resistance, glucose intolerance, obesity, steatosis, inflammation, and/or cancer.

[Pd(Cl)2(P(NC5H10)(C6H 11)2)2] - A highly effective and extremely versatile palladium-based negishi catalyst that efficiently and reliably operates at low catalyst loadings

[Pd(Cl)2(P(NC5H10)-(C6H 11)2]2] (1) has been prepared in quantitative yield by reacting commercially available [Pd(cod)(Cl)2] (cod = cyclooctadiene) with readily prepared 1-(dicyclohexylphosphanyl)piperidine in toluene under N2 within a few minutes at room temperature. Complex 1 has proved to be an excellent Negishi catalyst, capable of quantitatively coupling a wide variety of electronically activated, non-activated, deactivated, sterically hindered, heterocyclic, and functionalized aryl bromides with various (also heterocyclic) arylzinc reagents, typically within a few minutes at 100°C in the presence of just 0.01 mol% of catalyst. Aryl bromides containing nitro, nitrile, ether, ester, hydroxy, carbonyl, and carboxyl groups, as well as acetais, lactones, amides, anilines, alkenes, carboxylic acids, acetic acids, and pyridines and pyrimidines, have been successfully used as coupling partners. Furthermore, electronic and steric variations are tolerated in both reaction partners. Experimental observations strongly indicate that a molecular mechanism is operative.

Shape-dependent catalytic activity of copper oxide-supported Pd(0) nanoparticles for Suzuki and cyanation reactions

Palladium nanoparticles supported on different shapes of nanocrystalline CuO are prepared by the treatment of Cu(NO3)2 and Pd(OAc)2 in polyethylene glycol (PEG-6000). The shapes of the CuO/Pd composite are dependent on the amount of PEG used. Suzuki coupling was catalyzed efficiently by the oval-shaped material, whereas the rod shape facilitates the cyanation reaction. The CuO/Pd catalyst is recovered and reused for subsequent Suzuki reactions; however, cyanation poisons the catalyst for further use. Both these reactions are very clean and high yielding.

Palladium-Catalyzed Suzuki - Miyaura Cross-Couplings of Sulfonyl Chlorides and Boronic Acids

(Equation presented) Arene-, arylmethane, and alk-2-ene-1-sulfonyl chlorides undergo Suzuki - Miyaura cross-coupling with arene-, heteroarene-, and alkeneboronic acids in THF at reflux. The reactivity order is Arl > ArSO2Cl > ArBr ? ArCl.

Substituted phenyl farnesyltransferase inhibitors

Compounds of formula (I) or pharmaceutically acceptable salts thereof, inhibit farnesyltransferase. Methods for making the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.