56438-60-9

Upstream product

• 74882-11-4 Toluene-4-sulfonic acid 4-(2,3,4-trimethoxy-phenyl)-butyl ester 
• 74882-10-3 4-(2,3,4-trimethoxyphenyl)-1-bromobutane 
• 74882-09-0 4-(2,3,4-trimethoxyphenyl)butan-1-ol 
• 51686-50-1 methyl 3-(2,3,4-trimethoxybenzoyl)propionate 
• 51686-51-2 methyl 4-(2,3,4-trimethoxyphenyl)butanoate 
• 5406-18-8 3-(p-methoxyphenyl)-1-propanol 
• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 634-36-6 1,2,3-trimethoxybenzene 

Downstream Products

• 1569102-86-8 (R)-1-(2-(4-methoxyphenylethyl)-1,3-dithian-2-yl)pent-4-en-2-ol 
• 1569102-77-7 (3S,5R)-1-(4-methoxyphenyl)oct-7-ene-3,5-diol 
• 1569102-88-0 (R)-5-hydroxy-1-(4-methoxyphenyl)oct-7-en-3-one 
• 1443230-63-4 (3S,5R)-1-(4-methoxyphenyl)nonadecane-3,5-diol 
• 1443256-45-8 (3S,5R)-1-(4-hydroxyphenyl)nonadecane-3,5-diol 
• 1569102-85-7 (S)-2-((2-(4-methoxyphenylethyl)-1,3-dithian-2-yl)methyl)oxirane 
• 1428636-22-9 C₂₇H₄₆O₃S₂ 
• 1428636-18-3 (2R,4R)-4-((tert-butyldimethylsilyl)oxy)-1-(2-(4-methoxyphenethyl)-1,3-dithian-2-yl)pentadecan-2-ol 
• 1235479-26-1 (2R,4R)-4-[(tert-butyldimethylsilyl)oxy]-1-{[2-(4-methoxyphenyl)ethyl]-1,3-dithian-2-yl}heptadecan-2-ol 
• 74882-24-9 1-(4-Methoxy-phenyl)-7-(2,3,4-trimethoxy-phenyl)-heptan-3-one 
• 56438-65-4 Acetic acid 5-(4-methoxy-phenyl)-1-[2-(4-methoxy-phenyl)-ethyl]-3-oxo-pentyl ester 
• 56438-61-0 1,7-bis(4-methoxyphenyl)-5-hydroxyhept-3-one 
• 79422-46-1 1,7-bis(4-methoxyphenyl)-4-hepten-3-one 
• 79422-48-3 1,7-bis(3-iodo-4-methoxyphenyl)-4-hepten-3-one 

Relevant academic research and scientific papers

Stereoselective total synthesis of 4-((3S,5R)-3,5-dihydroxynonadecyl)phenol

A stereoselective total synthesis of 4-((3S,5R)-3,5-dihydroxynonadecyl) phenol has been accomplished in two different synthetic approaches. In the first approach, Prins cyclization has been successfully utilized to produce the anti-1,3-diol unit, which wa

Reaction of Aryl and Vinyl Halides with Zerovalent Nickel-Preparative Aspects and the Synthesis of Alnusone

Zerovalent nickel complexes such as bis(1,5-cyclooctadiene)nickel and tetrakis(triphenylphosphine)nickel react rapidly with aryl and vinyl halides to produce the symmetrical coupling products, a low-temperature analogue of the Ullman reaction.The reaction proceeds through oxidative addition of the organic halide to Ni(0), and the reactivity of the Ni(II)intermediates has been examined.Arylnickel halide complexes decompose rapidly to biaryls in DMF.The coupling of simple vinyl halides proceeds with isomerization of the double bond but 3-haloacrylates give efficient co upling with retention of geometry.Cyclizations to form ortho-bridged biaryls are efficient in simple cases (6-, 7-, 8-, 9-, 10-, and 14-membered rings) but fail with an ortho-disubstituted case.The 13-membered meta-bridged cyclic biphenyl, alnusone, is prepared efficiently with the crucial aryl halide coupling to form the ring proceeding in 50percent yield.A side reaction promoted by the presence of protons and with certain ortho-substituted aryl halides is reduction of the aryl halide to the arene.This process can be enhanced by deliberate addition of acid during reaction with Ni(0) and a series of aryl halides underwent succesful reduction.

Methods for the Construction of Linear 1,7-Diarylheptanoids; Synthesis of Di-O-methylcentrolobol and Precursors (Synthetic and Biosynthetic) to the meta,meta-Bridged Biphenyls Myricanol and Myricanone

1,7-diarylheptanoids are a varied natural product class in which 'linear' types appear to be biosynthetic precursors to macro(carbo)cyclic (3), macro(oxa)cyclic (4), and condensed polycyclic (5) examples.Various methods (suitable for radiolabelling) are described for constructing 'linear' diarylheptanoids, including Grignard couplings (employing activated magnesium) with arylpropanals and oxazonium salts (11a), (11h), (15a), and (15b)> and dithian alkylation (15c)>.Alkyl-lithium treatment of the benzyloxydithian (19b) gave 1,2,3-triphenylcyclopropane.Syntheses via trialkylcyanoborates were frustrated by disproportionation of the intermediate trialkylboranes.The diarylheptanoids synthesised (11a-h) and (15a-e) include synthetic and biosynthetic precursors to meta,meta-bridged biphenyls and related macrocyclic ethers.