56446-60-7Relevant articles and documents
Studies Towards the Total Synthesis of Taxoids: An Efficient Formal Total Synthesis of an A-seco Taxane Framework
Arseniyadis, S.,Wang, Q.,Yashunsky, D. V.,Kaoudi, T.,Alves, R. Brondi,Potier, P.
, p. 1633 - 1636 (1995)
Compounds 6 and 19 embodying the whole carbon framework and suitable functionalities of the taxane skeleton have been assembled starting from readily available chemicals.
Studies towards the total synthesis of taxoids: A rapid entry into bicyclo[6.4.0]dodecane ring system. Part 1
Arseniyadis, Simeon,Rico Ferreira, Maria Del Rosario,Del Moral, Jose Quilez,Hernando, Jose Ignacio Martin,Potier, Pierre,Toupet, Loic
, p. 4055 - 4071 (1998)
We report a short and stereocontrolled synthesis of the taxoid BC- subunit (+)-5 embodying the whole carbon framework and most of the required oxygen functionalities for further elaboration. Enantiomeric purity was secured at an early stage by resolution
Br?nsted acidic cellulose-PO3H: An efficient catalyst for the chemoselective synthesis of fructones and trans-esterification via condensation of acetoacetic esters with alcohols and diols
Naikwadi, Dhanaji R.,Singh, Amravati S.,Biradar, Ankush V.
, (2021/10/04)
Cellulose is the most abundant organic source and has expedient a great deal of interest as renewable and emerged as sustainable feedstock. The functionalization of cellulose as designed catalytic system intriguing furnished to the production of fine chemicals. Herein, we synthesized an environmental friendly solid acid catalyst by functionalizing cellulose with phosphoric acid (PO3H). The successful functionalization of cellulose with PO3H was confirmed by 31P NMR, ICP-OES, FE-SEM, and XPS analysis. ICP-OES revealed the presence of phosphorus content of ～1.0 wt. % on the catalyst's surface while elemental mapping by FESEM and XPS shows a uniform distribution of phosphorus over the material. The synthesized solid acid catalyst was utilized for condensation of diols with acetoacetic esters in solvent-free conditions to synthesize fine chemicals. The present approach not only circumvented the one-step protection and other products but more fascinatingly provided trans-esterification of acetoacetic esters with diols and n-alcohols. The catalyst was successfully used for chemoselective protection on ethyl acetoacetate with 1, 2 diols to essential fructone molecule with ～100% conversion and 99% selectivity. The results suggested that the catalyst has the advantage over commercial solid acid heterogeneous and homogeneous catalysts.
A method for the synthesis of the original drug of
-
Paragraph 0017; 0018, (2017/03/14)
The invention relates to the technical field of pharmaceutical chemical engineering, and discloses a synthetic method of a hymexazol raw pesticide. The synthetic method is characterized by comprising the following steps: adding methyl acetoacetate into a mixed solvent of ethylene glycol and cyclohexane, heating and refluxing, distilling to remove generated water under reduced pressure, after timely separating out the generated water, and distilling out cyclohexane under reduced pressure to obtain a compound A; after adding 8-hydroxyquinoline, ethylenediamine tetraacetic acid and water into hydroxylamine hydrochloride, stirring to completely dissolve the mixture, dropwise adding a sodium hydroxide solution at 5-10 DEG C, controlling PH to below 11-13, dropwise adding the sodium hydroxide solution while dropwise adding A, then heating up to 25-28 DEG C, and reacting to obtain a compound B; rapidly dropwise adding the compound B into concentrated hydrochloric acid while stirring, heating up to 70 DEG C, cooling to room temperature, dropwise adding the sodium hydroxide solution, filtering, cooling filtrate to 10-15 DEG C, adjusting the PH by using strong aqua, crystallizing at 5-10 DEG C, and drying. The synthetic method provided by the invention has the beneficial effects of easiness in synthesis, short reaction period, high yield, stable production, low cost, and high purity of products.
