564476-26-2Relevant academic research and scientific papers
Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors
Baloglu, Erkan,Miller, Michael L.,Roller, Elizabeth E.,Cavanagh, Emily E.,Leece, Barbara A.,Goldmacher, Victor S.,Chari, Ravi V.J.
, p. 5885 - 5888 (2007/10/03)
The use of drug-antibody conjugates affords a method for the targeted delivery of anticancer drugs specifically to cancer cells. Monoclonal antibodies alone usually do not possess high therapeutic efficacy, however, they are capable of targeting tumor mar
Synthesis of potent taxoids for tumor-specific delivery using monoclonal antibodies
Miller, Michael L.,Roller, Elizabeth E.,Wu, Xinyaun,Leece, Barbara A.,Goldmacher, Victor S.,Chari, Ravi V.J.,Ojima, Iwao
, p. 4079 - 4082 (2007/10/03)
The targeted delivery of taxoids, in the form of taxane-antibody immunoconjugates, requires the preparation of taxoids containing moieties suitable for their conjugation to monoclonal antibodies. A series of taxoids incorporating a disulfide-containing li
