653586-75-5Relevant academic research and scientific papers
Cytotoxic agents containing novel potent taxanes and their therapeutic use
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Page/Page column 16, Sheet 16, (2008/06/13)
Included within the scope of the present invention are potent taxanes containing a linking group. Also included is a cytotoxic agent comprising one or more taxanes linked to a cell binding agent. A therapeutic composition for inducing cell death in select
Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors
Baloglu, Erkan,Miller, Michael L.,Roller, Elizabeth E.,Cavanagh, Emily E.,Leece, Barbara A.,Goldmacher, Victor S.,Chari, Ravi V.J.
, p. 5885 - 5888 (2007/10/03)
The use of drug-antibody conjugates affords a method for the targeted delivery of anticancer drugs specifically to cancer cells. Monoclonal antibodies alone usually do not possess high therapeutic efficacy, however, they are capable of targeting tumor mar
