5586-70-9

Usage

Uses

1,6-Hexane diisothiocyanate is a useful research chemical.

InChI:InChI=1/C8H12N2S2/c11-7-9-5-3-1-2-4-6-10-8-12/h1-6H2

Upstream product

• 124-09-4 1,6-Hexanediamine 
• 102368-13-8 1,1'-Thiocarbonyldi-2(1H)-pyridone 
• 10017-50-2 hexamethylenedithioureide 
• 1370652-54-2 N,N'-hexanediyl bis-dithiocarbamic acid diphenyl ester 
• 463-71-8 thiophosgene 
• 19657-28-4 C₁₄H₂₄N₂O₄S₄ 
• 75-15-0 carbon disulfide 

Downstream Products

• 56473-16-6 1,1'-diphenyl-4,4'-hexanediyl-bis thiosemicarbazide 
• 47594-51-4 N',N''''-bis-(4-chloro-phenyl)-N,N'''-hexanediyl-di-guanidine 
• 56473-63-3 C₂₂H₂₈Cl₂N₈S₄ 
• 56473-61-1 C₂₄H₃₄N₈S₄ 
• 56602-52-9 C₂₆H₃₄N₈O₂S₂ 
• 56513-55-4 C₂₂H₄₂N₈S₄ 
• 56473-62-2 C₂₂H₃₀N₈S₄ 
• 56473-31-5 C₂₄H₂₈N₆O₄S₂ 
• 56473-33-7 C₂₄H₂₈N₆O₄S₂ 
• 56473-32-6 C₂₄H₂₈N₆O₄S₂ 
• 56473-42-8 1,1'-Di(p-nitro-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56473-41-7 1,1'-Di(m-nitro-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56473-37-1 1,1'-Di(m-brom-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 
• 56473-39-3 1,1'-Di(m-Chlor-benzoyl)-4,4'-hexamethylen-bis(thiosemicarbazid) 

Relevant academic research and scientific papers

Synthesis of isothiocyanates using DMT/NMM/TsO? as a new desulfurization reagent

Thirty-three alkyl and aryl isothiocyanates, as well as isothiocyanate derivatives from esters of coded amino acids and from esters of unnatural amino acids (6-aminocaproic, 4-(aminomethyl)benzoic, and tranexamic acids), were synthesized with satisfactory or very good yields (25–97%). Synthesis was performed in a “one-pot”, two-step procedure, in the presence of organic base (Et3 N, DBU or NMM), and carbon disulfide via dithiocarbamates, with 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium toluene-4-sulfonate (DMT/NMM/TsO? ) as a desulfurization reagent. For the synthesis of aliphatic and aromatic isothiocyanates, reactions were carried out in a microwave reactor, and selected alkyl isothiocyanates were also synthesized in aqueous medium with high yields (72–96%). Isothiocyanate derivatives of L-and D-amino acid methyl esters were synthesized, under conditions without microwave radiation assistance, with low racemization (er 99 > 1), and their absolute configuration was confirmed by circular dichroism. Isothiocyanate derivatives of natural and unnatural amino acids were evaluated for antibacterial activity on E. coli and S. aureus bacterial strains, where the most active was ITC 9e.

Method for jointly preparing isothiocyanate and phosphorus, nitrogen and sulfur flame retardants

The invention discloses a method for jointly preparing isothiocyanate and phosphorus, nitrogen and sulfur flame retardants. The method comprises the following steps: taking amine and CS2 as raw materials; generating dithiocarbamate by reacting in a solvent under the existence of alkali; reacting with neopentyl glycol phosphoryl chloride, thereby acquiring an isothiocyanate compound (I); acidizingby-product 1,3,2-phosphorus dioxidehexane thiophosphate (II); generating a salt by reacting with melamine in the solvent, thereby acquiring the phosphorus, nitrogen and sulfur flame retardants (III).According to the method provided by the invention, isothiocyanate and phosphorus, nitrogen and sulfur flame retardants can be jointly prepared; operation is simple and convenient; product yield is high; atom is economical; the prepared phosphorus, nitrogen and sulfur flame retardants (III) have an excellent anti-flaming effect.

T3P - A Benign Desulfurating Reagent in the Synthesis of Isothiocyanates

A number of alkyl, aryl and bifunctional isothiocyanates are obtained in moderate to high yields (41-94%) in a two-step, one-pot reaction of the parent primary amines or their salts with carbon disulfide, followed by reaction of the thus formed dithiocarbamates with T3P (propane phosphonic acid anhydride) as a new and efficient desulfurating agent.

A sulfur key Lian Niao multifunctional synergistic antioxidant stabilizer preparation method

The invention relates to a preparation method of a multi-functional synergetic anti-oxidative stabilizer for sulfide bond linked urea. The preparation method comprises the following steps: (1) adding organic amine into CS2 and alkali to react; adding meth

A thiourea multifunctional synergistic antioxidant stabilizer and its preparation method and application

The invention relates to a multi-functional synergetic anti-oxidative stabilizer for thiourea as well as a preparation method and application thereof. The multi-functional synergetic anti-oxidative stabilizer has a structure shown in the specification, wh

ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION

The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

ISOTHIOCYANATE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Provided herein are compositions of matter and pharmaceutical compositions thereof, for use in inhibiting the growth of various microbial pathogens, including bacteria, fungi, protozoa, and viral pathogens. Also provided herein are methods of treating microbial diseases/infections and cancer with the compositions. The compositions are additionally useful in wood preservation and food preservation by inhibition of microbial growth.

ISOTHIOCYANATE PRODUCTION METHOD, COMPOSITION FOR TRANSPORTING AND STORING N-SUBSTITUTED O-SUBSTITUTED THIOCARBAMATE, AND ISOTHIOCYANATE COMPOSITION

The present invention relates to an isothiocyanate production method using an organic primary amine and thiourea as starting materials; to a composition for transporting and storing an N-substituted O-substituted thiocarbamate that includes an N-substituted O-substituted thiocarbamate and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the carbamate groups of the N-substituted O-substituted thiocarbamate being in the range of 1 to 100; to a composition for transporting and storing a compound with a thioureido group that includes a compound with a thioureido group and a hydroxy compound, the equivalent weight ratio of hydroxy groups of the hydroxy compound with respect to the thioureido groups of the compound with a thioureido group being in the range of 1 to 100; and to an isothiocyanate composition containing an isothiocyanate and a compound with a specific functional group.

Influence of linker length in shape recognition of B? DNA by dimeric aminoglycosides

Abstract DNA-protein recognition has shown us the importance of DNA shapes in the recognition process. Specific high-affinity targeting of DNA shapes by small molecules is desirable for many biological applications that involve regulation of DNA based pro

SEPARATION METHOD

The present invention provides a separation method of separating (A) and (B), comprising: a step of separating at least either an active hydrogen-containing compound (A) or a compound (B) that reversibly reacts with (A) from a mixture containing (A) and (B) by distillation in a multistage distillation column; and a step of supplying the mixture to an inactive region formed within the multistage distillation column.