565214-84-8Relevant academic research and scientific papers
Non-defluorinative electrochemical silylation of ethyl trifluoroacetate: A practical synthesis of trifluoroacetyltrimethylsilane via its ethyltrimethylsilyl ketal
Bordeau, Michel,Clavel, Philipe,Barba, Alic,Berlande, Muriel,Biran, Claude,Roques, Nicolas
, p. 3741 - 3744 (2003)
An efficient method for the preparation of original trifluoroacetyltrimethylsilane, CF3COSiMe3 (3), in two steps from readily available ethyl trifluoroacetate is described. Electrochemical reduction of this ester using a sacrificial anode and performed on a semimolar scale afforded the unprecedented corresponding ketal, CF3C(SiMe3)(OSiMe3)OEt (2) in 30-56% isolated yield. Treated with concentrated sulphuric acid at room temperature, the latter directly led to pure acylsilane 3 in 86% yield.
Defluorination-silylation of alkyl trifluoroacetates to 2,2-difluoro-2-(trimethylsilyl)acetates by copper-deposited magnesium and trimethylsilyl chloride
Utsumi, Shinya,Katagiri, Toshimasa,Uneyama, Kenji
experimental part, p. 580 - 583 (2012/01/14)
Reductive defluorination-silylation of alkyl trifluoroacetates with copper-deposited magnesium and trimethylsilyl chloride (TMS-Cl) gave 2,2-difluoro-2-(trimethylsilyl)acetates, potential difluoromethylene building blocks, in 60-68% yields.
