56531-62-5Relevant academic research and scientific papers
Discovery of Adamantane Carboxamides as Ebola Virus Cell Entry and Glycoprotein Inhibitors
Plewe, Michael B.,Sokolova, Nadezda V.,Gantla, Vidyasagar Reddy,Brown, Eric R.,Naik, Shibani,Fetsko, Alexandra,Lorimer, Donald D.,Lorimer, Donald D.,Dranow, David M.,Dranow, David M.,Smutney, Hayden,Smutney, Hayden,Bullen, Jameson,Bullen, Jameson,Sidhu, Rana,Sidhu, Rana,Master, Arshil,Master, Arshil,Wang, Junru,Wang, Junru,Kallel, E. Adam,Zhang, Lihong,Kalveram, Birte,Freiberg, Alexander N.,Henkel, Greg,McCormack, Ken
supporting information, p. 1160 - 1167 (2020/05/14)
We identified and explored the structure-activity-relationship (SAR) of an adamantane carboxamide chemical series of Ebola virus (EBOV) inhibitors. Selected analogs exhibited half-maximal inhibitory concentrations (EC50 values) of ～10-15 nM in vesicular s
ADAMANTANE DERIVATIVES FOR THE TREATMENT OF FILOVIRUS INFECTION
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Paragraph 0898-0899; 0902-0903, (2020/02/05)
Compounds of structural Formula I were developed for the treatment of infections by filoviruses including Ebolavirus and Marburgvirus, wherein, R1, R2, R3, X and Y are defined in the specification.
SPHINGOSINE KINASE INHIBITOR PRODRUGS
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Page/Page column 36-37, (2010/10/03)
The invention relates to prodrugs of hydroxyl-substituted adamantane compounds, pharmaceutical compositions thereof, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease
SPHINGOSINE KINASE INHIBITORS
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Page/Page column 34-35, (2008/06/13)
The invention relates to substituted adamantane compounds, pharmaceutical compositions thereof, processes for their preparation, and methods for inhibiting sphingosine kinase and for treating or preventing hyperproliferative disease, inflammatory disease, or angiogenic disease.
