565473-06-5

Usage

Uses

Used in Pharmaceutical Synthesis:
1H-Imidazole-4-carbonitrile, 5-amino-2-bromo-1-(phenylmethyl)is used as a building block in the synthesis of pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs.
Used in Agrochemical Synthesis:
1H-Imidazole-4-carbonitrile, 5-amino-2-bromo-1-(phenylmethyl)is also used in the synthesis of agrochemicals, contributing to the development of new pesticides and other agricultural products.
Used in Anticancer Research:
1H-Imidazole-4-carbonitrile, 5-amino-2-bromo-1-(phenylmethyl)has potential biological activity as an anticancer agent. Its unique structure allows it to interact with cellular targets, making it a promising candidate for further research and development in cancer treatment.
Used in Antiviral Research:
In addition to its potential as an anticancer agent, 1H-Imidazole-4-carbonitrile, 5-amino-2-bromo-1-(phenylmethyl)- also has potential biological activity as an antiviral agent. Its ability to interact with viral targets makes it a candidate for further research in the development of antiviral therapies.
Used in Organic Synthesis:
1H-Imidazole-4-carbonitrile, 5-amino-2-bromo-1-(phenylmethyl)is used as a building block in organic synthesis for the production of various other compounds. Its versatile structure and functional groups make it a valuable component in the synthesis of a wide range of organic compounds.

Upstream product

• 60598-48-3 5-amino-1-benzyl-1H-imidazole-4-carbonitrile 

Downstream Products

• 565473-07-6 9-benzyl-8-bromo-2-hydroxyadenine 
• 914110-68-2 9-benzyl-8-bromo-2-(trichloromethyl)-9H-purin-6-amine 
• 1434584-96-9 C₁₈H₁₇N₇O 
• 1434588-28-9 C₁₈H₁₈N₆O₃ 
• 914110-71-7 6-amino-9-benzyl-8-oxo-8,9-dihydro-7H-purine-2-carboxylic acid 
• 914110-60-4 methyl 6-amino-9-benzyl-8-methoxy-9H-purine-2-carboxylate 
• 914110-70-6 methyl 6-amino-9-benzyl-8-oxo-8,9-dihydro-7H-purine-2-carboxylate 
• 1434585-12-2 C₁₅H₁₃N₇O 
• 947146-57-8 1-benzyl-2-bromo-5-iodo-1H-imidazole-4-carbonitrile 
• 226907-89-7 9-benzyl-8-bromo-2-pentoxyadenine 
• 226908-79-8 9-benzyl-8-methoxy-2-pentoxyadenine 
• 226908-78-7 9-benzyl-2-butoxy-8-methoxyadenine 
• 226907-88-6 9-benzyl-8-bromo-2-butoxy-9H-purine-6-amine 
• 226908-23-2 9-benzyl-8-methoxy-2-propoxyadenine 

Relevant academic research and scientific papers

PURINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

2-AMIDO-6-AMINO-8-OXOPURINE DERIVATIVES AS TOLL-LIKE RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER AND VIRAL INFECTIONS, SUCH AS HEPATITIS C

This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. The present invention provides compounds of formula (I) wherein R1, R2, R3, R9, R9a and Y are defined in the description. More particularly, the present invention relates to the use of purine derivatives in the treatment of a variety of viral infections and immune or inflammatory disorders, including those in which the modulation, in particular agonism, of Toll-Like Receptors (TLRs) is implicated. Accordingly, the compounds of the invention are useful in the treatment of infectious disease such as Hepatitis (e.g. HCV, HBV), genetically related viral infections, inflammatory diseases such as asthma and arthritis, and cancer.

Efficient synthesis of 2,9-disubstituted 8-hydroxyadenine derivatives

An efficient and general method for the synthesis of 2,9-disubstituted 8-hydroxyadenines, which are expected to have various biological activities, was realized. 5-amino-4-cyano-2-hydroxyimidazoles(1) were prepared from aminomalononitrile and isocyanates as key intermediates. The condensation of 1a with amidines, imidates, guanidine, urea and thioureas afforded 8-hydroxyadenines (2-6) possessing various substituents at the 2-position. Furthermore, selective alkylation of 2-amino- and 2-hydroxyadenines (4 and 6) successively proceeded to give the corresponding 2-alkylamino- and 2-alkoxyadenines (5 and 7), respectively. 2-Alkythioadenines (15) were prepared by an analogous reaction of 1a with benzoyl isothiocyanate and subsequent S-alkylation. The imidazoles 1 are most useful intermediated for the synthesis of 8-hydroxyadenine derivatives.