226908-79-8

Upstream product

• 56046-25-4 6-amino-9-benzyl-2-chloropurine 
• 565473-07-6 9-benzyl-8-bromo-2-hydroxyadenine 
• 565473-06-5 5-amino-1-benzyl-2-bromo-1H-imidazole-4-carbonitrile 
• 60598-48-3 5-amino-1-benzyl-1H-imidazole-4-carbonitrile 
• 226907-84-2 6-Amino-9-benzyl-2-pentoxypurine 
• 124-41-4 sodium methylate 
• 226907-89-7 9-benzyl-8-bromo-2-pentoxyadenine 
• 67-56-1 methanol 

Relevant academic research and scientific papers

Synthesis and evaluation of 2-substituted 8-hydroxyadenines as potent interferon inducers with improved oral bioavailabilities

In order to create novel compounds which possess potent interferon (IFN) inducing activities with excellent oral bioavailabilities, a series of 8-hydroxyadenines, which have various alkoxy or alkylthio moieties at the adenine C(2)-position, were synthesiz

Efficient synthesis of 2,9-disubstituted 8-hydroxyadenine derivatives

An efficient and general method for the synthesis of 2,9-disubstituted 8-hydroxyadenines, which are expected to have various biological activities, was realized. 5-amino-4-cyano-2-hydroxyimidazoles(1) were prepared from aminomalononitrile and isocyanates as key intermediates. The condensation of 1a with amidines, imidates, guanidine, urea and thioureas afforded 8-hydroxyadenines (2-6) possessing various substituents at the 2-position. Furthermore, selective alkylation of 2-amino- and 2-hydroxyadenines (4 and 6) successively proceeded to give the corresponding 2-alkylamino- and 2-alkoxyadenines (5 and 7), respectively. 2-Alkythioadenines (15) were prepared by an analogous reaction of 1a with benzoyl isothiocyanate and subsequent S-alkylation. The imidazoles 1 are most useful intermediated for the synthesis of 8-hydroxyadenine derivatives.