5655-25-4Relevant academic research and scientific papers
Multicomponent Condensation Reactions via ortho-Quinone Methides
Allen, Emily E.,Zhu, Calvin,Panek, James S.,Schaus, Scott E.
, p. 1878 - 1881 (2017/04/11)
Iron(III) salts promote the condensation of aldehydes or acetals with electron-rich phenols to generate ortho-quinone methides that undergo Diels - Alder condensations with alkenes. The reaction sequence occurs in a single vessel to afford benzopyrans in up to 95% yield. The reaction was discovered while investigating a two-component strategy using 2-(hydroxy(phenyl)methyl)phenols to access the desired ortho-quinone methide in a Diels - Alder condensation. The two-component condensation also afforded the corresponding benzopyran products in yields up to 97%. Taken together, the two- and three-component strategies using ortho-quinone methide intermediates provide efficient access to benzopyrans in good yields and selectivities.
Novel Route for the Construction of Chroman Ring System Using Cross-Coupling between Benzylic and Aliphatic Alcohols in the Presence of NaHSO4/SiO2
Aoyama, Tadashi,Furukawa, Takuya,Hayakawa, Mamiko,Takido, Toshio,Kodomari, Mitsuo
supporting information, p. 1875 - 1879 (2015/08/06)
Novel route for the construction of chromans from benzylic and aliphatic alcohols in the presence of NaHSO4/SiO2 has been developed. In this reaction, substituted olefins are formed from benzylic and aliphatic alcohols and then conve
