56558-97-5Relevant academic research and scientific papers
Synthesis of 2-isoxazolyl-2,3-dihydrobenzofuransviapalladium-catalyzed cascade cyclization of alkenyl ethers
Zhou, Fei,Li, Can,Li, Meng,Jin, Yangbin,Jiang, Huanfeng,Zhang, Yingjun,Wu, Wanqing
supporting information, p. 4799 - 4802 (2021/05/25)
A novel palladium-catalyzed cascade cyclization reaction of alkenyl ethers with alkynyl oxime ethers for the construction of poly-heterocyclic scaffolds has been developed, in which the electron-rich alkene moiety functions as a three-atom unit, simultaneously dealing well with the coordination and regioselectivity of electron-rich olefins under metal catalysis. The strategy features excellent regio- and chemoselectivities as well as good functional group tolerance. Moreover, the newly formed 2-isoxazolyl-2,3-dihydrobenzofuran products can be further transformed to diverse complex heterocycles, demonstrating their potential applications in organic synthesis and medicinal chemistry.
Alkyne derivative as well as preparation method and application thereof (by machine translation)
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Paragraph 0108-0113, (2020/06/05)
The invention belongs to the technical field of organic synthesis, and discloses an acetylenic ketone derivative and a preparation method and application thereof. The formula (I) is shown in the structural formula of the alkyne derivative. R1 And R2 Heterocyclyl groups of C1 - C20, halogen, ester, carbonyl, nitro, substituted amino, C5 - C30, or C5 - C30, respectively. To the strategy of nickel catalytic reduction coupling, a carboxylic acid derivative which is widely used in nature is used as a substrate, an alkyne halide is combined as an active alkynylation reagent, and under the condition of room temperature, the universality and the high efficiency method for rapidly constructing various substituted alkynes are obtained. The alkyne compound disclosed by the invention not only can be used as a practical synthesis, but also can be used as a precursor of heterocyclic compounds such as furan, pyrazole, quinoline, pyrimidine and the like. (by machine translation)
Palladium-catalyzed carbonylative sonogashira coupling of aryl bromides via tert -butyl isocyanide insertion
Tang, Ting,Fei, Xiang-Dong,Ge, Zhi-Yuan,Chen, Zhong,Zhu, Yong-Ming,Ji, Shun-Jun
, p. 3170 - 3175 (2013/06/27)
A simple and efficient palladium-catalyzed carbonylative Sonogashira coupling via tert-butyl isocyanide insertion has been developed, which demonstrates the utility of isocyanides in intermolecular C-C bond construction. This methodology provides a novel pathway for the synthesis of alkynyl imines which can undergo simple silica gel catalyzed hydrolysis to afford alkynones. The approach is tolerant of a wide range of substrates and applicable to library synthesis.
