56578-39-3

Basic information

• Product Name: 2-PROPENAL, 3-(3-NITROPHENYL)-,(2E)
• Synonyms: M-NITROCINNAMALDEHYDE;2-PROPENAL, 3-(3-NITROPHENYL)-,(2E);3-NITROCINNAMALDEHYDE;(2E)-3-(3-nitrophenyl)prop-2-enal
• CAS NO: 56578-39-3
• Molecular Formula: C₉H₇NO₃
• Molecular Weight: 177.16
• Mol File: 56578-39-3.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 337.1 °C at 760 mmHg
• Flash Point: 170.2 °C
• Appearance: /
• Density: 1.269 g/cm³
• Vapor Pressure: 0.000107mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-PROPENAL, 3-(3-NITROPHENYL)-,(2E)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-PROPENAL, 3-(3-NITROPHENYL)-,(2E)(56578-39-3)
• EPA Substance Registry System: 2-PROPENAL, 3-(3-NITROPHENYL)-,(2E)(56578-39-3)

Safety Data

• Hazardous Substances Data: 56578-39-3(Hazardous Substances Data)

Usage

General Description

2-PROPENAL, 3-(3-NITROPHENYL)-,(2E) is a chemical compound with the molecular formula C9H7NO3. It is also known as 2-propenal, 3-(3-nitrophenyl)-, (2E) and is a yellow to light-brown solid with a pungent odor. 2-PROPENAL, 3-(3-NITROPHENYL)-,(2E) is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a flavoring agent in the food industry. 2-PROPENAL, 3-(3-NITROPHENYL)-,(2E) has potential health effects, including irritation to the skin, eyes, and respiratory system, and is considered harmful if ingested. Proper handling and protective measures are necessary when working with this compound.

InChI:InChI=1/C9H7NO3/c11-6-2-4-8-3-1-5-9(7-8)10(12)13/h1-7H/b4-2+

Upstream product

• 1772-65-2 (E)-4-(3-nitrophenyl)-2-oxo-3-butenoic acid 
• 35418-05-4 (E)-3-nitrocinnamic acid chloride 
• 99-61-6 3-nitro-benzaldehyde 
• 2136-75-6 (triphenylphosphoranylidene)acetaldehyde 
• 1504-64-9 (E)-3-(3-nitrophenyl)prop-2-en-1-ol 
• 107-02-8 acrolein 
• 63307-44-8 3-(3-nitrophenyl)-1-propanol 
• 645-00-1 m-iodonitrobenzene 
• 198783-53-8 3-(3-nitrophenyl)propanal 
• 75-07-0 acetaldehyde 

Downstream Products

• 115951-96-7 2,6-Dimethyl-4-[(E)-2-(3-nitro-phenyl)-vinyl]-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 130973-09-0 (E)-3-(3-nitrophenyl)acrylamide 
• 31145-08-1 trans-3-(3-nitrophenyl)acrylonitrile 
• 70076-42-5 ethyl 3-oxo-5-(3-nitrophenyl)-4-(E)-pentenoate 

Relevant articles and documents

NOVEL COMPOUNDS USEFUL AS NEAR-INFRARED FLUORESCENT PROBES SELECTIVELY BINDING TO TAU AGGREGATES AND METHOD OF PREPARING THE SAME

Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells

Two series of racemic goniothalamin analogues displaying nitrogen-containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF-7 (0.5 μm) and PC3 (0.3 μm) cells, about 26-fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco-2 cells (IC50=0.8 μm), about 10-fold more potent and 17-fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF-7, Caco-2, and PC3 cancer cell lines.

Gold catalyzed Heck-coupling of arenediazonium o-benzenedisulfonimides

Diazonium salts, and precisely arenediazonium o-benzenedisulfonimides, have been used for the first time as efficient electrophilic partners in gold catalyzed Heck-coupling reactions. The synthetic protocol was general, easy and gave the target products in satisfactory yields. Mechanistic insights revealed the fundamental roles of the o-benzenedisulfonimide anion as an electron transfer agent thath promotes a radical pathway that does not require the presence of photocatalysts or external oxidants.