56598-40-4Relevant academic research and scientific papers
SELF-IMMOLATIVE SYSTEMS
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Page/Page column 10; 13; 14, (2020/05/28)
The present invention is concerned with self-immolative recognition and/or responsive systems for electrophilic compounds, especially alkylating agents, which systems may comprise disclosure or detection of the alkylating agent. The present invention is especially concerned with non-protic triggered self-immolative systems, molecules, and methods, and in particular for detection of non- protic electrophilic agents, and especially alkylating agents, for example alkyl or benzylic halides, which may be found in pesticides or fumigants, or chemical warfare agents.
Self-immolative systems for the disclosure of reactive electrophilic alkylating agents
Acton, Aaron L.,Leroux, Flavien,Feula, Antonio,Melia, Kelly,Sambrook, Mark R.,Hayes, Wayne,Russell, Andrew T.
, p. 5219 - 5222 (2019/05/07)
In this paper we report the design, synthesis and assessment of the first examples of self-immolative systems triggered by non-acidic electrophilic agents such as methyl, allyl or benzylic halides. These systems provide a visual colorimetric disclosure response upon exposure to these electrophilic reagents under mild, basic conditions without the need for the use of analytical instrumentation.
THE 2-(DIPHENYLPHOSPHINO)ETHYL GROUP (DPPE) AS A NEW CARBOXYL-PROTECTING GROUP IN PEPTIDE CHEMISTRY
Chantreux, Dominique,Gamet, Jean-Paul,Jacquier, Robert,Verducci, Jean
, p. 3087 - 3094 (2007/10/02)
The use of 2-(diphenylphosphino)ethyl group for carboxyl-protection of amino acids or peptides is described.This group is easily introduced by esterification using 2-(diphenylphosphino)ethanol in the presence of dicyclohexylcarbodiimide and 4-(dimethylamino)pyridine.These Dppe esters are stable under the standard conditions for peptide synthesis.Deprotection is carried out under mild conditions by quaternisation using methyl iodide followed by a β-elimination induced by fluoride ion or potassium carbonate.
