566-63-2

Usage

Uses

Used in Pharmaceutical Industry:
(17α)-3β-Hydroxypregn-5-en-20-one is used as an intermediate compound in the synthesis of various steroid hormones for pharmaceutical applications. Its role in the steroidogenesis process makes it a valuable component in the development of drugs targeting hormonal imbalances and related conditions.
Used in Neurological Applications:
As a GABAA antagonist, (17α)-3β-Hydroxypregn-5-en-20-one is used in the development of treatments for neurological disorders related to the GABAergic system. Its ability to increase neurogenesis in the hippocampus also makes it a potential candidate for therapies aimed at improving cognitive function and addressing neurodegenerative diseases.
Used in Research and Development:
(17α)-3β-Hydroxypregn-5-en-20-one is utilized as a research tool in the study of steroid hormone synthesis, metabolism, and their effects on various physiological processes. Its presence as an impurity in Pregnenolone production also makes it relevant for quality control and optimization of steroid hormone manufacturing processes.

InChI:InChI=1/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4,15-19,23H,5-12H2,1-3H3/t15-,16-,17-,18-,19-,20-,21+/m0/s1

Upstream product

• 979-02-2 16-dehydropregnenolone acetate 
• 1093959-59-1 3β-hydroxypregn-5-en-20-one-3-acetate 
• 387-79-1 17-Hydroxypregnenolone 
• 60-29-7 diethyl ether 
• 53-43-0 dehydroepiandrosterone 
• 141-52-6 sodium ethanolate 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 

Downstream Products

• 24199-63-1 {4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-acetic acid (3S,8S,9S,10R,13S,14S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 57-83-0 Progesterone 
• 53-43-0 dehydroepiandrosterone 
• 1164-98-3 3β-21-Dihydroxy-5-pregnen-20-one 
• 91414-17-4 3β-hydroxy-20-phenylselenopregna-5,17-diene 
• 57-83-0 progesterone 
• 1232-18-4 17-Ethyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 2862-58-0 (S)-17-Ethyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 
• 566-65-4 dihydroprogesterone 

Relevant academic research and scientific papers

Proline-promoted dehydroxylation of α-ketols

A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups.

Steroidal androgen receptor inhibitor as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, in particular relates to a steroidal androgen receptor inhibitor as well as a preparation method and medical application thereof, and particularly discloses medicines for treating related diseases of an androgen receptor, for example, cell proliferation dependent on androgen, hirsutism, acnes, androgenetic alopecia and the like. The general structural formula of the compound is as shown in the specification; and group definitions in the general formula are specified in the specification.