5662-75-9

Basic information

• Product Name: 6-Phosphonohexanoic acid
• Synonyms: 6-Phosphonohexanoic acid;6-Phosphonohexanoic acid 97%;(5-Carboxypentyl)phosphonic acid
• CAS NO: 5662-75-9
• Molecular Formula: C₆H₁₃O₅P
• Molecular Weight: 196.14
• Product Categories: Phosphonic AcidsOrganic Building Blocks;Phosphonic/Phosphinic Acids;Phosphorus Compounds;Self Assembly&Contact Printing;Self-Assembly Materials;Phosphonic Acids;Building Blocks;Chemical Synthesis;Contact Printing;Materials Science;Micro/NanoElectronics;Organic Building Blocks;Phosphonic/Phosphinic Acids;Phosphorus Compounds;Self Assembly &Self-Assembly Materials
• Mol File: 5662-75-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 98-104 °C
• Appearance: /
• CAS DataBase Reference: 6-Phosphonohexanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Phosphonohexanoic acid(5662-75-9)
• EPA Substance Registry System: 6-Phosphonohexanoic acid(5662-75-9)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 5662-75-9(Hazardous Substances Data)

Usage

Uses

6-Phosphonohexanoic Acid is used in the organophosphonate biofunctionalization of diamond electrodes.

General Description

6-Phosphonohexanoic acid (PHA) is an alkylphosphonic acid that forms a self-assembled monolayer (SAM) on a variety of surfaces. It has carboxylic groups that facilitate the grafting of the surface atoms while the phosphonic groups allow the surface modification of the substrate material.

Upstream product

• 54965-29-6 6-(diethoxyphosphoryl)hexanoic acid ethyl ester 
• 25542-62-5 6-bromo-hexanoic acid ethyl ester 
• 14273-90-6 methyl 6-bromohexanoate 
• 4224-70-8 6-bromohexanoic acid 
• 151163-57-4 6-(diethoxyphosphoryl)hexanoic acid methyl ester 

Downstream Products

• 287396-91-2 4-Nitrobenzyl 6-[bis(4-nitrobenzyloxy)phosphoryl]hexanoate 
• 287396-90-1 6-[Hydroxy(4-nitrobenzyloxy)phosphoryl]hexanoic acid 

Relevant articles and documents

Biodegradable magnetic nanocarrier for stimuli responsive drug release

Biocompatible nanocarriers conjugated with magnetic nanoparticle, doxorubicin and poly(ethylene oxide) (PEG) motif have been designed (PVLPEG-PVLDOXI-PCL-PHOS) to create a magnetic vector under magnetic field. Acylhydrazine linker is used to release the drug exactly at the mild acidic conditions resembling the pH of the cancerous cells. All the monomers and polymers are characterized carefully by the routine analytical techniques. Thermogravimetric analysis (TGA), FT-IR spectroscopy and scanning electron microscope (SEM) techniques are employed to confirm the anchoring of iron particle (Fe3O4) to the PVLPEG-PVLDOXI-PCL-PHOS. Reservoir capabilities of the newly designed biodegradable nanocarrier are tested by both dynamic light scattering (DLS) and transmission electron microscopy (TEM). Drug release profile from nanocarrier is monitored by fluorimeter. The release profile shows the importance of having the acylhydrazine linker that helps to release the drug at the mild acidic conditions similar to cancerous cells. Confocal laser scanning microscopy (CLSM) and flow cytometry studies on 4T cells indicate that nanocarriers from PVLPEG-PVLDOXI-PCL-PHOS polymer are internalized efficiently. It is very interesting to note that the nanocarriers have exhibited both biologically and magnetically targeting abilities toward 4T cells in vitro.

A comparison of phosphonothioic acids with phosphonic acids as phosphatase inhibitors

Phosphorothioates, analogues of phosphate esters in which a sulfur replaces an oxygen atom in the phosphoryl group, are competent surrogate substrates for a number of phosphatases. In some cases the thio analogues show similar binding (as estimated by Ks