56620-28-1

Basic information

• Product Name: 8-Azabicyclo[3.2.1]octan-2-one, 8-methyl-, (1R,5S)-
• CAS NO: 56620-28-1
• Molecular Formula: C8H13NO
• Molecular Weight: 139.197
• Mol File: 56620-28-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-Azabicyclo[3.2.1]octan-2-one, 8-methyl-, (1R,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Azabicyclo[3.2.1]octan-2-one, 8-methyl-, (1R,5S)-(56620-28-1)
• EPA Substance Registry System: 8-Azabicyclo[3.2.1]octan-2-one, 8-methyl-, (1R,5S)-(56620-28-1)

Safety Data

• Hazardous Substances Data: 56620-28-1(Hazardous Substances Data)

Upstream product

• 53-21-4 (-)-cocaine hydrochloride 
• 74242-55-0 anhydroecgonine hydrochloride 
• 484-93-5 ecgonidine 
• 50373-10-9 methyl ecgonidine 
• 85506-18-9 (1R)-(-)-2-carbomethoxy-3-tropinone 

Downstream Products

• 36127-54-5 (+)-2α-tropanol 
• 36127-15-8 (1R)-tropane-2exo-ol 
• 936564-33-9 (1R,5S)-N-benzyloxycarbonyl-2-oxo-8-azabicyclo[3.2.1]octane 
• 936564-35-1 (1R,5S)-N-benzyloxycarbonyl-2-methoxy-8-azabicyclo[3.2.1]oct-2-ene 
• 936564-37-3 (2R,5S)-N-benzyloxycarbonyl-2-methoxycarbonyl-5-(2-oxoethyl)-pyrrolidine 
• 936564-39-5 (2R,5S)-N-benzyloxycarbonyl-2-methoxycarbonyl-5-(2,2-dimethoxyethyl)-pyrrolidine 
• 540709-45-3 (1R,5S)-8-methyl-2-(pyridin-3'-yl)-8-azabicyclo[3.2.1]oct-2-ene 
• 5424-16-8 3-endo-amino-8-methyl-8-azabicyclo[3.2.1.]octane bis-hydrochloride 

Relevant articles and documents

Synthesis of optically pure epibatidine analogs: (1R, 2R, 5S)-2β-(2-chloro-5-pyridinyl)-8-azabicyclo[3.2.1]octane and (1R, 2S, 5S)-2α-(2-chloro-5-pyridinyl)-8-azabicyclo[3.2.1]octane from (-)-cocaine

Two optically pure epibatidine analogs, 4 and 5, which contain the 8-azabicyclo[3.2.1]octane ring system were synthesized from (-)-cocaine. The nicotinic receptor binding affinity and the stimulant activity of 4 and 5 were measured to be significantly lower than racemic epibatidine (±-1).

COMPOUNDS AND METHODS FOR PREVENTING OR TREATING SENSORY HAIR CELL DEATH

Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.