56658-05-0

Upstream product

• 56658-04-9 2-bromo-5-methoxybenzoyl chloride 
• 124-68-5 2-Amino-2-methyl-1-propanol 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 

Downstream Products

• 60081-44-9 4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methoxy-phenyl]-1-methyl-piperidin-4-ol 
• 744995-13-9 1-benzyl-4-[2-(4,4-dimethyl-4,5-dihydro-oxazol-2-yl)-4-methoxy-phenyl]-piperidin-4-ol 
• 60081-45-0 1'-benzyl-5-methoxy-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 866526-30-9 4,5-dihydro-4,4-dimethyl-2-(5-methoxy-2-(diphenylphosphino)phenyl)oxazole 
• 56658-06-1 2-(2-bromo-5-methoxy-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole 

Relevant academic research and scientific papers

C-H to C-N Cross-Coupling of Sulfonamides with Olefins

Cross-coupling of nitrogen with hydrocarbons under fragment coupling conditions stands to significantly impact chemical synthesis. Herein, we disclose a C(sp3)-N fragment coupling reaction between terminal olefins and N-triflyl protected aliphatic and aromatic amines via Pd(II)/SOX (sulfoxide-oxazoline) catalyzed intermolecular allylic C-H amination. A range of (56) allylic amines are furnished in good yields (avg. 75%) and excellent regio- and stereoselectivity (avg. >20:1 linear:branched, >20:1 E:Z). Mechanistic studies reveal that the SOX ligand framework is effective at promoting functionalization by supporting cationic π-allyl Pd.

Nickel(II) complexes bearing phosphinooxazoline ligands: Synthesis, structures and their ethylene oligomerization behaviors

A series of Ni(II) complexes 4a-f ligated by the unsymmetrical phosphino-oxazolines (PHOX) were synthesized and characterized by elemental analysis and IR spectroscopy, and the structures of complexes 4c-4e were confirmed by the X-ray crystallographic analysis. All derivatives showed distorted tetrahedron geometry by the nickel center and coordinative atoms. Upon activation with methylaluminoxane (MAO) or Et2AlCl, these complexes exhibited considerable to high activity of ethylene oligomerization. The ligands environments and reaction conditions significantly affect their catalytic activities, while the highest oligomerization activity (up to 1.18 × 106 g ? mol-1(Ni) ? h-1) was observed for 4d at 20 atm of ethylene. Incorporation of 2-4 equivalents of PPh 3 as auxiliary ligands in the 4a-f/MAO catalytic systems led to higher activity and longer catalytic lifetime.