56677-60-2

Basic information

• Product Name: Myristyl chloroformate
• Synonyms: MYRISTYLCHLOROFORMATE;tetradecyl chloroformate;Chloroformic acid tetradecyl ester;chlorocarbonic acid myristyl ester;tetradecyl carbonochloridate;Tetradecyl chloroforMate ester;Carbonochloridic acid,tetradecyl ester
• CAS NO: 56677-60-2
• Molecular Formula: C₁₅H₂₉ClO₂
• Molecular Weight: 276.84
• EINECS: 260-330-8
• Product Categories: CHLOROFORMATES
• Mol File: 56677-60-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 335.7 °C at 760 mmHg
• Flash Point: 113 °C
• Appearance: /
• Density: 0.951 g/cm³
• Vapor Pressure: 0.000118mmHg at 25°C
• Refractive Index: 1.449
• CAS DataBase Reference: Myristyl chloroformate(CAS DataBase Reference)
• NIST Chemistry Reference: Myristyl chloroformate(56677-60-2)
• EPA Substance Registry System: Myristyl chloroformate(56677-60-2)

Safety Data

• Hazardous Substances Data: 56677-60-2(Hazardous Substances Data)

Usage

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C15H29ClO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-15(16)17/h2-14H2,1H3

Upstream product

• 112-72-1 1-Tetradecanol 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 75-44-5 phosgene 

Relevant articles and documents

Anti-HIV-Active Nucleoside Triphosphate Prodrugs

We disclose a study on nucleoside triphosphate (NTP) analogues in which the γ-phosphate is covalently modified by two different biodegradable masking units and d4T as nucleoside analogue that enable the delivery of d4TTP with high selectivity in phosphate buffer (pH 7.3) and by enzyme-triggered reactions in human CD4+ T-lymphocyte CEM cell extracts. This allows the bypass of all steps normally needed in the intracellular phosphorylation. These TriPPPro-nucleotides comprising an acyloxybenzyl (AB; ester) or an alkoxycarbonyloxybenzyl (ACB; carbonate) in combination with an ACB moiety are described as NTP delivery systems. The introduction of these two different groups led to the selective formation of γ-(ACB)-d4TTPs by chemical hydrolysis and in particular by cell extract enzymes. γ-(AB)-d4TTPs are faster cleaved than γ-(ACB)-d4TTPs. In antiviral assays, the compounds are highly active against HIV-1 and HIV-2 in wild-type CEM/O cells and more importantly in thymidine kinase-deficient CD4+ T-cells (CEM/TK-).

Method for stabilizing synthetic thermoplastic materials against thermal degradation

The present invention relates to a novel method for stabilizing synthetic thermoplastic materials against thermal degradation, which comprises incorporating in said materials one or more compounds of the formula (I) STR1 in which R1 is unsubstituted or substituted phenyl, n is e.g. 1, 2 or 3, and, when n is 1, R2 is e.g. --COR3, --COOR4 or --CO-N(R5)R6 in which R3 is e.g. C4 -C17 alkyl, R4 is e.g. C4 -C18 alkyl, cyclohexyl or t-butylcyclohexyl, R5 and R6 which can be identical or different are e.g. C2 -C8 alkyl or cyclohexyl, and, when n is 2, R2 is e.g. --CO--R10 --OC, --COO-R11 --OOC-- or --CONH--R12 --NHCO- in which R10 is e.g. C2 -C8 alkylene, R11 is e.g. C4 -C6 alkylene and R12 is e.g. C4 -C6 alkylene, and, when n is 3, R2 is e.g. benzenetricarbonyl. Several compounds of the formula (I) are new.