56697-99-5Relevant academic research and scientific papers
A versatile preparation of alpha,beta-unsaturated lactones from homoallylic alcohols.
Keck,Li,Knutson
, p. 411 - 413 (1999)
[formula: see text] A new method for the synthesis of alpha,beta-unsaturated lactones from beta-acetoxy aldehydes by reaction with the lithium enolate of methyl acetate was developed. The reaction is relatively insensitive to structural changes in the ald
Tishchenko reactions of aldehydes promoted by diisobutylaluminum hydride and its application to the macrocyclic lactone formation
Hon, Yung-Son,Wong, Ying-Chieh,Chang, Chun-Ping,Hsieh, Cheng-Han
, p. 11325 - 11340 (2008/03/12)
Aliphatic aldehydes react with catalytic amount of Dibal-H in n-pentane to give the corresponding Tishchenko products in good to excellent yields. On contrary, α-silyloxy aldehydes give α-silyloxy ketones via Oppenauer oxidation under similar condition. Tishchenko reaction of ω-alkene aldehydes followed by RCM and hydrogenation affords a convenient method to prepare the 11-37 membered macrocyclic lactones.
Antianaphylactic agents. 1. 2-(Acylamino)oxazoles
Ross,Harrison,Jolley,Neville,Todd,Verge,Dawson,Sweatman
, p. 412 - 417 (2007/10/08)
The synthesis and biological properties of 35 2-(acylamino)oxazoles are described. The majority of the compounds inhibit the release of slow-reacting substance of anaphylaxis (SRS-A) in vitro from sensitized guinea pig chopped lung. In addition, several of the compounds inhibited the release of SRS-A from passively sensitized human chopped lung and protected guinea pigs from the effects of anaphylaxis in a modified Herxheimer test.
Preparation of α-acetoxy aldehydes and ketones
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, (2008/06/13)
An improved method for the preparation of intermediates of formula: EQU1 WHERE R1 and R2 represent hydrogen, C1-4 alkyl, C1-4 hydroxyalkyl, C3-10 cycloalkyl, C3/
