199293-83-9

Usage

Uses

Used in Biochemistry and Molecular Biology Applications:
NSP-SA-NHS is used as a labeling agent for various biomolecules, including proteins, antigens, antibodies, and nucleic acids (DNA, RNA). Its ability to label these molecules allows for their detection, quantification, and tracking in various experimental setups.
Used in Chemiluminescent Immunoassays:
NSP-SA-NHS is employed as a chemiluminescent label in immunoassays, enabling rapid and sensitive detection of target molecules. One example is its use in a chemiluminescence immunoassay for Bisphenol A, where it provides a highly sensitive and specific detection method.
Used in Diagnostics:
In the diagnostics industry, NSP-SA-NHS can be used as a component in the development of diagnostic tests, particularly those involving the detection and quantification of specific proteins, antigens, or nucleic acids.
Used in Research and Development:
NSP-SA-NHS is a valuable tool in research and development, where it can be utilized to study the interactions and properties of various biomolecules, as well as to develop new methods and techniques for molecular biology and biochemistry.

Upstream product

• 5672-89-9 N-trifluoroacetoxy succinimide 
• 211106-69-3 9-[[(3-carboxypropyl)[(4-methylphenyl)sulfonyl]amino]carbonyl]-10-(3-sulfopropyl)-acridinium inner salt 
• 5132-80-9 acridine-9-carbonyl chloride hydrochloride 
• 118429-43-9 4-[(4-methylphenyl)sulfonylamino]butyric acid methyl ester 
• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 215929-59-2 C₆₄H₆₉N₇O₁₇S₄ 
• 676161-19-6 NSP-AS-HD-theophylline conjugate 
• 676161-20-9 NSP-AS-ED-carbamazepine conjugate 
• 676161-17-4 3-[9-({(3-carboxypropyl)[(4-methylphenyl) sulfonyl] amino}carbonyl)-10-acridiniumyl]-1-propanesulfonate-valproate 

Relevant academic research and scientific papers

Synthesis of a chemiluminescent acridinium hydroxylamine (AHA) for the direct detection of abasic sites in DNA

Formula presented The synthesis of a chemiluminescent acridinium hydroxylamine (AHA) for the direct detection of abasic sites in damaged nucleic acids is described. The reagent reacts readily with abasic sites of damaged calf thymus DNA generated in a tim

Evaluation of chemiluminescent estradiol conjugates by using a surface plasmon resonance detector

A series of chemiluminescent 17β-estradiol probes were synthesized. Relative equilibrium dissociation constants (K(D)) for the interaction of an anti-E2 Fab fragment for the probes in solution were evaluated using a single E2-analog biosensor surface on a BIAcore surface plasmon resonance instrument. The results show the antibody fragment binds all chemiluminescent conjugates tested with high affinity showing only minor preferences for site of substitution (C6 versus C7), stereochemistry (α versus β), or linker moiety. (C) 2000 Elsevier Science Inc.

Preparation method of acridine inner salt

The invention discloses a preparation method of acridine inner salt. The method specifically comprises the following steps: by taking a compound with a structure as shown in a formula C as a raw material, adding an activating agent into an acetonitrile so

Tracermer signal generators: an arborescent approach to the incorporation of multiple chemiluminescent labels.

The synthesis, conjugation, and chemiluminescent evaluation of zero, first, and second order acridinium-based Tracermer signal generators are described. Members of this family of labels have potential use as tracers in diagnostic assays and are structurally similar to arborol dendrimers. Tracermer-BSA conjugates showed up to a sixfold increase in light emission compared to the normal acridinium label.