56724-14-2Relevant academic research and scientific papers
Synthesis and neurotoxic potential of racemic and chiral dihydroxytetrahydroquinoline derivatives
Lewis, Russell J.,Francis, Charles A.,Lehr, Roland E.,Leroy Blank
, p. 5345 - 5352 (2007/10/03)
The synthesis and preliminary neurotoxic investigation of (±), (+) and (-)-3-amino-6,7-dihydroxy-1,2,3,4-tetrahydroquinoline, (±)-3-amino-6,8-dihydroxy-1,2,3,4-tetrahydroquinoline and (±)-3-aminomethyl-6,7-dihydroxy-1,2,3,4-tetrahydroquinoline are described. While exhibiting relatively no dopamine and only moderate norepinephrine depletions, these compounds elicit serotonin depletions equal to those provided by the well-known serotonergic neurotoxin 5,7-dihydroxytryptamine in whole mouse brain. (C) 2000 Elsevier Science Ltd.
