1097-21-8Relevant academic research and scientific papers
Synthesis and neurotoxic potential of racemic and chiral dihydroxytetrahydroquinoline derivatives
Lewis, Russell J.,Francis, Charles A.,Lehr, Roland E.,Leroy Blank
, p. 5345 - 5352 (2007/10/03)
The synthesis and preliminary neurotoxic investigation of (±), (+) and (-)-3-amino-6,7-dihydroxy-1,2,3,4-tetrahydroquinoline, (±)-3-amino-6,8-dihydroxy-1,2,3,4-tetrahydroquinoline and (±)-3-aminomethyl-6,7-dihydroxy-1,2,3,4-tetrahydroquinoline are described. While exhibiting relatively no dopamine and only moderate norepinephrine depletions, these compounds elicit serotonin depletions equal to those provided by the well-known serotonergic neurotoxin 5,7-dihydroxytryptamine in whole mouse brain. (C) 2000 Elsevier Science Ltd.
Combretastatin Analogs via Hydration of Stilbene Derivatives
Mannila, Erkki,Talvitie, Antti
, p. 1037 - 1040 (2007/10/02)
Hydration of the double bond of some stilbene congeners of Picea abies bark by TiCl4.NaBH4 reagent is described.Five racemic 1,2-diphenylethanol derivatives (9-13), structurally related to (R)-(-)combretastatin , have been obtained and characterize
