56733-21-2

Upstream product

• 578-95-0 10H-acridin-9-one 
• 91-40-7 2-(phenylamino)benzoic acid 
• 4357-57-7 9-bromoacridine 
• 88-65-3 2-bromobenzoic-acid 
• 62-53-3 aniline 
• 74-88-4 methyl iodide 
• 602-56-2 9-phenylacridine 

Downstream Products

• 602-56-2 9-phenylacridine 
• 74-88-4 methyl iodide 
• 71576-19-7 10-methyl-9-phenyl-9,10-dihydro-acridine-9-carbonitrile 
• 99682-60-7 9-methoxy-10-methyl-9-phenyl-9,10-dihydroacridine 
• 5464-91-5 10-methyl-9-phenylacridin-10-ium chloride 

Relevant academic research and scientific papers

Electrochemical, Spectroscopic, and Quantum Chemical Study of Electrocatalytic Hydrogen Evolution in the Presence of N-Methyl-9-phenylacridinium Iodide

Main intermediates in the electrocatalytic hydrogen evolution promoted by N-methyl-9-phenyl-acridinium iodide have been identified and characterized using cyclic voltammetry (CV) and NMR and ESR spectroscopy. A probable mechanism of the process has been p

Design of Novel Catalysts Based on Acridine Derivatives Immobilized on Carbon Materials for Molecular Hydrogen Production

Immobilization of acridine and its derivatives (9-phenylacridine and N-methyl-9-phenylacridinium iodide) has been studied and quantitative data on physical adsorption have been obtained. The adsorption equilibrium constants K, the parameters A∞

Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents

With the increasing incidence of antibiotic resistance, new antibacterial agents having novel mechanisms of action hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Four novel series of substituted 9-arylalkyl-10-methylacridinium derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. The results demonstrated that they exhibited broad-spectrum activities with substantial efficacy against MRSA and VRE, which were superior or comparable to the berberine, sanguinarine, linezolid, ciprofloxacin and vancomycin. In particular, the most promising compound 15f showed rapid bactericidal properties, which avoid the emergence of drug resistance. However, 15f showed no inhibitory effect on Gram-negative bacteria but biofilm formation study gave possible answers. Further target identification and mechanistic studies revealed that 15f functioned as an effective FtsZ inhibitor to alter the dynamics of FtsZ self-polymerization, which resulted in termination of the cell division and caused cell death. Further cytotoxicity and animal studies demonstrated that 15f not only displayed efficacy in a murine model of bacteremia in vivo, but also no significant hemolysis to mammalian cells. Overall, this compound with novel skeleton could serve as an antibacterial lead of FtsZ inhibitor for further evaluation of drug-likeness.

Compound, pharmaceutical composition, medicine and application of compound, pharmaceutical composition and medicine in preparation of antibacterial products

The invention particularly relates to a compound, a pharmaceutical composition, a medicine and application of the compound, the pharmaceutical composition and the medicine in preparation of antibacterial products. The seeking of a novel antibacterial target and the development of a novel chemical entity have important significance for solving the increasingly severe bacterial drug resistance problem at present, and the design of a compound entity acting on the FtsZ target is expected to be developed to obtain an antibacterial drug which has no influence on a host. The invention provides a 9-aralkyl-10-methylacridine quaternary ammonium salt derivative and a preparation method thereof, and the compound has significant bactericidal and/or bacteriostatic activity on gram-positive bacteria, has a good effect of inhibiting bacterial division protein FtsZ, and can be used for preparing antibacterial products.

Acridinium salts as metal-free electrocatalyst for hydrogen evolution reaction

Here we report the purely organic metal-free electrocatalyst - acridinium salt 9-phenyl-10-methylacridinium iodide for hydrogen evolution reaction. A controlled potential electrolysis experiment in present 9-phenyl-10-methylacridinium iodide with a simult

Carbon nanotube-acridine nanohybrids: Spectroscopic characterization of photoinduced electron transfer

Single-walled carbon nanotubes (NT) were covalently functionalized with either 9-phenyl acridine (PhA) or 10-methyl-9-phenyl acridinium (PhMeA +). Absorption and fluorescence properties of acridine derivatives tethered to the nanotubes were studied in homogeneous dispersions. Exciplex emission was observed for NT functionalized with 9-phenylacridine. This phenomenon was attributed to an " intramolecular" interaction between excited phenyl acridine and carbon nanotubes. Interestingly, reverse photoinduced electron transfer from the nanotube to 10-methyl-9-phenylacridinium was detected for the NTPhMeA+ nanohybrid. This electron transfer led to a strong quenching of the acridinium fluorescence and to the formation of a metastable acridine radical. Evidence for the formation of this radical was obtained by ESR studies.

Photochemical properties of 9-(4-azidophenyl)acridine

Syntheses are reported for 9-(azidophenyl)acridine and the corresponding N-methylacridine derivative, which have absorption bands in the near-UV and visible spectral regions. The photodissociation quantum yields upon irradiation of these azides at the lon

Thermal and Photochemical Reactions of 10-Mehtyl-9-phenylacridinium Chloride in Alcohols

The photoreduction of 10-methyl-9-phenylacridinium chloride in methanol containing K2CO3 involves the nucleophilic addition of methanol to the 9-position of the acridinium cation, the photoinduced heterolysis of the methanol adduct, and the hydride transf