4357-57-7Relevant articles and documents
Isolation and low-temperature X-ray analysis of intramolecular triarylmethane-triarylmethylium complex: Preference for a C-H-bridged unsymmetric structure exhibiting a facile 1,5-hydride shift and charge-transfer interaction
Kawai, Hidetoshi,Takeda, Takashi,Fujiwara, Kenshu,Suzuki, Takanori
, p. 12172 - 12173 (2005)
The intramolecular triarylmethane-methylium complex with an averaged C2v-symmetry was successfully generated by N-methylation of the acridine-acridan hybrid. Theoretical calculation and VT-NMR analyses in solution indicate the unsymmetric geometry for the three-center bond, which was finally confirmed crystallographically. Significant degree of CT interaction is induced through the very short C-H...C+ contact. Copyright
Design, synthesis and evaluation of novel 9-arylalkyl-10-methylacridinium derivatives as highly potent FtsZ-targeting antibacterial agents
Song, Di,Zhang, Nan,Zhang, Panpan,Zhang, Na,Chen, Weijin,Zhang, Long,Guo, Ting,Gu, Xiaotong,Ma, Shutao
, (2021/05/10)
With the increasing incidence of antibiotic resistance, new antibacterial agents having novel mechanisms of action hence are in an urgent need to combat infectious diseases caused by multidrug-resistant (MDR) pathogens. Four novel series of substituted 9-arylalkyl-10-methylacridinium derivatives as FtsZ inhibitors were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. The results demonstrated that they exhibited broad-spectrum activities with substantial efficacy against MRSA and VRE, which were superior or comparable to the berberine, sanguinarine, linezolid, ciprofloxacin and vancomycin. In particular, the most promising compound 15f showed rapid bactericidal properties, which avoid the emergence of drug resistance. However, 15f showed no inhibitory effect on Gram-negative bacteria but biofilm formation study gave possible answers. Further target identification and mechanistic studies revealed that 15f functioned as an effective FtsZ inhibitor to alter the dynamics of FtsZ self-polymerization, which resulted in termination of the cell division and caused cell death. Further cytotoxicity and animal studies demonstrated that 15f not only displayed efficacy in a murine model of bacteremia in vivo, but also no significant hemolysis to mammalian cells. Overall, this compound with novel skeleton could serve as an antibacterial lead of FtsZ inhibitor for further evaluation of drug-likeness.
Novel acridine compound and organic light-emitting devices thereof
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Paragraph 0083; 0084; 0085, (2017/10/23)
The invention provides a novel acridine compound and organic light-emitting devices thereof, belongs to the technical field of organic photoelectric materials, and aims to solve the technical problems of low light-emitting efficiency, high driving voltage, short service life and low light-emitting performance of the organic photoelectric material in the prior art. Compared with the prior art, the light-emitting performance of the organic light-emitting devices based on organic electroluminescence device compounds and ink compositions can be obviously improved; the novel acridine compound is used as an excellent OLED material.
