56768-53-7

Basic information

• Product Name: N-(4-cyanophenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(4-cyanophenyl)-4-methylbenzenesulfonamide
• CAS NO: 56768-53-7
• Molecular Formula: C₁₄H₁₂N₂O₂S
• Molecular Weight: 272.32228
• Mol File: 56768-53-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 457.2°Cat760mmHg
• Flash Point: 230.3°C
• Appearance: /
• Density: 1.33g/cm³
• Vapor Pressure: 1.52E-08mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: N-(4-cyanophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-cyanophenyl)-4-methylbenzenesulfonamide(56768-53-7)
• EPA Substance Registry System: N-(4-cyanophenyl)-4-methylbenzenesulfonamide(56768-53-7)

Safety Data

• Hazardous Substances Data: 56768-53-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H12N2O2S/c1-11-2-8-14(9-3-11)19(17,18)16-13-6-4-12(10-15)5-7-13/h2-9,16H,1H3

Upstream product

• 31125-07-2 4-cyanonitrosobenzene 
• 106-49-0 p-toluidine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 70-55-3 toluene-4-sulfonamide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 619-72-7 4-nitrobenzonitrile 
• 941-55-9 4-toluenesulfonyl azide 
• 98-59-9 p-toluenesulfonyl chloride 
• 873-74-5 4-Aminobenzonitrile 

Downstream Products

• 1418757-93-3 N-(4-(4-aminohepta-1,6-dien-4-yl)phenyl)-4-methylbenzenesulfonamide 
• 1418756-64-5 C₃₀H₂₅N₃O₄S₂ 

Relevant articles and documents

Metal-free one-pot synthesis of N-arylsulfonamides from nitroarenes and sodium sulfinates in an aqueous medium

A metal-free one-pot two-step synthesis of sulfonamides from readily available nitroarenes and sodium arylsulfinates in a mixture of methanol and water has been developed. In this procedure, the aryl amines were produced in situ by the reduction of nitroarenes mediated by diboronic acid, and then coupled with sodium arylsulfinates in the presence of iodine. A series of N-arylsulfonamides with various functional groups were obtained in moderate to good yields under the optimal reaction conditions. In addition, this one-pot process is applicable for gram-scale synthesis.

Transition-Metal-Free and Visible-Light-Mediated Desulfonylation and Dehalogenation Reactions: Hantzsch Ester Anion as Electron and Hydrogen Atom Donor

Novel approaches for N- and O-desulfonylation under room temperature (rt) and transition-metal-free conditions have been developed. The first methodology involves the transformation of a variety of N-sulfonyl heterocycles and phenyl benzenesulfonates to the corresponding desulfonylated products in good to excellent yields using only KOtBu in dimethyl sulfoxide (DMSO) at rt. Alternately, a visible light method has been used for deprotection of N-methyl-N-arylsulfonamides with Hantzsch ester (HE) anion serving as the visible-light-absorbing reagent and electron and hydrogen atom donor to promote the desulfonylation reaction. The HE anion can be easily prepared in situ by reaction of the corresponding HE with KOtBu in DMSO at rt. Both protocols were further explored in terms of synthetic scope as well as mechanistic aspects to rationalize key features of desulfonylation processes. Furthermore, the HE anion induces reductive dehalogenation reaction of aryl halides under visible light irradiation.

Hexaacyl reductive cercosporin photocatalyst, and preparation method and application thereof

The invention discloses a hexacyloyl reductive cercosporin photocatalyst and preparation and application thereof, belonging to the technical field of preparation methods and organic synthesis of catalysts. The preparation method comprises the following steps: adding anhydride into a mixture of cercosporin, a reducing agent and alkali, carrying out stirring at room temperature for 1-3 hours, addinganhydride, continuing reacting for 1-3 hours, and carrying out suction filtration, extraction, concentration and column chromatography purification to obtain the catalyst. The catalyst provided by the invention can catalyze reduction, coupling and other photochemical reactions of halogenated hydrocarbons, and has strong reaction activity and industrialization prospects.