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1-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine is a chemical compound with the molecular formula C10H8F3N3. It is a derivative of indazole, a bicyclic aromatic compound consisting of a benzene ring fused to a pyrazole ring. The presence of a methyl group at the 1-position and a trifluoromethyl group at the 5-position gives 1-METHYL-5-(TRIFLUOROMETHYL)-1H-INDAZOL-3-AMINE unique properties and potential applications in various fields, such as pharmaceuticals and agrochemicals. The amine group at the 3-position allows for further functionalization and modification, making it a versatile building block for the synthesis of more complex molecules.

5685-69-8

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5685-69-8 Usage

Class

Indazoles

Explanation

Heterocyclic compounds containing a five-membered ring with three carbon atoms and two nitrogen atoms.

Explanation

TRKs are kinase enzymes involved in promoting cell growth and survival.

Explanation

The compound's ability to target TRKs makes it a potential candidate for the development of new cancer therapies.

Explanation

The presence of the trifluoromethyl group improves the compound's stability and its behavior within the body, making it more effective as a pharmaceutical agent.

Explanation

Due to its ability to target TRKs and its enhanced properties, 1-Methyl-5-(trifluoromethyl)-1H-indazol-3-amine has the potential to be a significant agent in the future of cancer treatment and therapy development.

Function

Potent and selective inhibitor of TRKs (tropomyosin receptor kinases)

Preclinical Studies

Treatment of various types of cancers

Examples

Colorectal, gastric cancer, and neuroblastoma

Trifluoromethyl group

Enhanced metabolic stability and pharmacokinetic properties

Potential

Important pharmaceutical agent

Check Digit Verification of cas no

The CAS Registry Mumber 5685-69-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,6,8 and 5 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 5685-69:
(6*5)+(5*6)+(4*8)+(3*5)+(2*6)+(1*9)=128
128 % 10 = 8
So 5685-69-8 is a valid CAS Registry Number.

5685-69-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Amino-1-methyl-5-(trifluoromethyl)-1H-indazole

1.2 Other means of identification

Product number -
Other names 1-methyl-5-(trifluoromethyl)indazol-3-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:5685-69-8 SDS

5685-69-8Downstream Products

5685-69-8Relevant academic research and scientific papers

HETEROCYCLIC COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS

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Page/Page column 29; 33, (2021/11/20)

The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and

Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

Zhang, Xuqing,Hufnagel, Heather,Hou, Cuifen,Opas, Evan,McKenney, Sandra,Crysler, Carl,O'Neill, John,Johnson, Dana,Sui, Zhihua

supporting information; experimental part, p. 6042 - 6048 (2011/11/06)

A novel series of 4-azetidinyl-1-aryl-cyclohexanes containing indazole or benzoisoxazole moiety have been identified as potent CCR2 antagonists with high selectivity versus hERG.

CYCLOHEXYL-AZETIDINYL ANTAGONISTS OF CCR2

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Page/Page column 57, (2012/01/03)

The present invention comprises compounds of Formula (I). wherein: R1, R2, X, and Z are as defined in the specification. The invention also comprises a method of preventing, treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is type II diabetes, obesity and asthma. The invention also comprises a method of inhibiting CCR2 activity in a mammal by administration of a therapeutically effective amount of at least one compound of Formula (I).

GLUCOKINASE ACTIVATORS

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Page/Page column 89-91, (2010/11/27)

Compounds, pharmaceutical compositions, kits and methods are provided for use with glucokinase that comprise a compound selected from the group consisting of wherein the variables are as defined herein.

Cyclic derivatives as modulators of chemokine receptor activity

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, (2008/06/13)

The present application describes modulators of MCP-1 of formula (I): or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis, asthma, restinosis, organ transplantation, and

3-Aminoindazole derivatives

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, (2008/06/13)

.Iadd.Pharmaceutical compositions having muscle relaxant and analgesic activity containing 3-aminoindazoles..Iaddend.

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