56875-97-9

Upstream product

• 141-97-9 ethyl acetoacetate 
• 83-38-5 2,6-dichlorobenzaldehyde 
• 57-13-6 urea 

Downstream Products

• 1240793-14-9 ethyl 6-methyl-4-(2,6-dichlorophenyl)pyrimidin-2(1H)-one-5-carboxylate 

Relevant academic research and scientific papers

Simple protocol for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones using SnCl2·2H2O-LiCl as an inexpensive catalyst system

A one-pot synthesis of the 3,4-dihydropyrimidin-2(1H)-ones catalyzed by tin chloride-lithium chloride combination catalyst system involving three component heteroannular cyclization is reported.

Phosphotungstic acid grafted zeolite imidazolate framework as an effective heterogeneous nanocatalyst for the one-pot solvent-free synthesis of 3,4-dihydropyrimidinones

Phosphotungstic acid (H3PW12O40, PTA) supported on ZIF-9(NH2) was synthesized for the first time and performed as an effective and environmental friendly catalyst in the one-pot three component Biginelli condens

Synthesis, cytotoxic assessment, and molecular docking studies of 2,6-diaryl-substituted pyridine and 3,4-dihydropyrimidine-2(1H)-one scaffolds

Cancer is one of the main global health problems. In order to develop novel antitumor agents, we synthesized 3,4-dihydropyrimidine-2(1H)-one (DHPM) and 2,6-diaryl-substituted pyridine derivatives as potential antitumor structures and evaluated their cytot

Xanthine oxidase inhibitory and molecular docking studies on pyrimidones

Background: Xanthine oxidase is an important enzyme which catalyzes the production of uric acid and superoxide anion from xanthine. The over-production of these products leads to different disease conditions. For instance, uric acid is responsible for hyp

Pyridinium-based bronsted acidic ionic liquid as a highly efficient catalyst for one-pot synthesis of dihydropyrimidinones

In this work, the synthesis and characterization of 3-carboxypyridinium hydrogensulfate ([Hcpy]HSO4) as a new Brnsted acidic ionic liquid are reported. This reusable, inexpensive, and green catalyst was employed for one-pot condensation of 1,3-

Al2O3/MeSO3H: A novel and recyclable catalyst for one-pot synthesis of 3,4-dihydropyrimidinones or their sulfur derivatives in Biginelli condensation

Al2O3/CH3SO3H (AMA) is an efficient catalyst for the three-component condensation reaction of aldehyde, 1,3-dicarbonyl compound, and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2-(1H)-ones in high isolated yield via this procedure, w

Microwave-assisted efficient synthesis of dihydro pyrimidines: Improved high yielding protocol for the Biginelli reaction

DihydropyrJmidJnes were synthesJsed in high yields by one-pot cyclocondensation reaction of aldehydes, aceto-acetates and urea using various acid catalysts like Amberlyst-15, Nafion-H, KSF clay and dry acetic acid under microwave irradiation.