ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Base Information

• Chemical Name: ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate
• CAS No.: 56875-97-9
• Molecular Formula: C₁₄H₁₄Cl₂N₂O₃
• Molecular Weight: 329.183
• Mol file: 56875-97-9.mol

Synonyms:ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property of ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate

There total 2 articles about ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl acetoacetate (141-97-9) + 2,6-dichlorobenzaldehyde (83-38-5) + urea (57-13-6) → ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (56875-97-9)

Guidance literature:

With SO₃H-substituted silica-coated CoFe₂O₄-based magnetic nanoparticles; In neat (no solvent); for 0.05h; Microwave irradiation;

DOI:10.3906/kim-1903-72

Reference yield:

→ ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (56875-97-9)

Guidance literature:

2,6-Dichlor-benzaldehyd, CH3-CO-CH2-COOC2H5, Harnstoff, HCl;

Reference yield: 94.0%

ethyl-4-(2,6-dichlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate (56875-97-9) → ethyl 6-methyl-4-(2,6-dichlorophenyl)pyrimidin-2(1H)-one-5-carboxylate (1240793-14-9)

Guidance literature:

With oxygen; zinc(II) oxide; In acetonitrile; at 20 ℃; for 4.5h; UV-irradiation;

upstream raw materials:

ethyl acetoacetate

2,6-dichlorobenzaldehyde

urea

Downstream raw materials:

ethyl 6-methyl-4-(2,6-dichlorophenyl)pyrimidin-2(1H)-one-5-carboxylate