56879-46-0

Usage

Uses

Used in Pharmaceutical Industry:
Homoproline is used as a GABA-uptake inhibitor for its potential role in modulating the levels of gamma-aminobutyric acid (GABA) in the brain. GABA is a neurotransmitter that helps regulate neuronal excitability and has been linked to various neurological and psychiatric disorders. By inhibiting GABA uptake, homoproline may help improve the symptoms of conditions such as anxiety, epilepsy, and depression.
Used in Melampodium divaricatum:
Homoproline is used as a bioactive compound derived from the plant Melampodium divaricatum. This plant has been traditionally used in folk medicine for its various therapeutic properties. The isolation of homoproline from this plant source highlights its potential as a natural therapeutic agent with GABA-uptake inhibitory activity.

InChI:InChI=1/C6H11NO2/c8-6(9)4-5-2-1-3-7-5/h5,7H,1-4H2,(H,8,9)

Upstream product

• 141-82-2 malonic acid 
• 5981-17-9 dodecahydro-3a,6a,9a-triaza-trindene 

Downstream Products

• 813433-68-0 2-methoxycarbonylmethylpyrrolidine-1-carboxylic acid tert-butyl ester 
• 170491-63-1 N-Boc-prolinol 
• 1590382-14-1 C₂₉H₄₃N₆O₃S⁽¹⁺⁾*C₅H₁₀NO₄S^(1-) 

Relevant academic research and scientific papers

Enzymatic resolution of cyclic N-Boc protected β-aminoacids

Methyl and ethyl esters of N-Boc homoproline, homopipecolic acid and 3-carboxymethyl-morpholine were kinetically resolved by hydrolysis catalysed by Burkholderia cepacia lipase to give the corresponding acids and residual esters in enantiomeric excesses better than 99% (E > 100).

Decarboxylation Reaction. X. Introduction of a Carbon unit at the α-Position of Amines by Reaction of Hexahydro-1,3,5-triazines with Carboxylic Acids

An efficient method for introducing a carbon unit at the α-position of alicyclic amines is described.The method involves the reaction of monocyclic or tetracyclic hexahydro-1,3,5-triazines with trichloroacetic acid, cyanoacetic acid, malonic acid and their derivatives, which are introduced into the α-position of amines in the decarboxylated form.Keywords --- 1,3,5-trialkylhexahydro-1,3,5-triazine; trimer of alicyclic imine; decarboxylation; β-amino acid; carboxylic acid

INTRODUCTION OF CARBON UNIT AT THE α-POSITION OF ALICYCLIC AMINES UTILIZING A DECARBOXYLATION REACTION WITH MALONIC ACID DERIVATIVES

A new method for introducing carbon unit at the α-position of alicyclic amines has been exploited.The method involves a reaction of trimers of alicyclic imines with malonic acid derivatives, of which decarboxylation leads to a formation of carbon-carbon bond at the α-position of alicyclic amines.