56886-07-8

Upstream product

• 104-94-9 4-methoxy-aniline 
• 1694-29-7 3-chloropentane-2,4-dione 
• 4346-59-2 para-methoxyphenyldiazonium chloride 

Downstream Products

• 61323-07-7 1-[1-(4-methoxy-phenyl)-5,5-di-morpholin-4-yl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone 
• 56885-97-3 2-[5-acetyl-3-(4-methoxy-phenyl)-3H-[1,3,4]thiadiazol-2-ylidene]-1-p-tolyl-ethanone 
• 56885-94-0 1-[5-acetyl-3-(4-methoxy-phenyl)-3H-[1,3,4]thiadiazol-2-ylidene]-propan-2-one 
• 139455-70-2 (S)-3-Acetyl-1-(4-methoxy-phenyl)-5-methyl-4,5-dihydro-1H-[1,2,4]triazin-6-one 
• 71687-15-5 1-[5-imino-4-(4-methoxy-phenyl)-4,5-dihydro-[1,3,4]thiadiazol-2-yl]-ethanone 
• 153937-40-7 1-[5-Amino-1-(4-methoxy-phenyl)-1H-[1,2,4]triazol-3-yl]-ethanone 
• 1177417-10-5 3-acetyl-1-(4-methoxyphenyl)-6,7,8,9-tetrahydrobenzo[4,5]-thieno[2,3-d]-1,2,4-triazolo[4,5-a]pyrimidin-5-one 
• 118318-04-0 1-[(4S,5R)-5-Benzoyl-4-(4-chloro-phenyl)-1-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-ethanone 
• 136515-05-4 1-[6-Furan-2-yl-5-(4-methoxy-phenyl)-2-methyl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-yl]-ethanone 
• 136515-02-1 1-[5-(4-Methoxy-phenyl)-2-methyl-6-thiophen-2-yl-1,2,5,6-tetrahydro-[1,2,4,5]tetrazin-3-yl]-ethanone 
• 118318-01-7 1-[(4S,5R)-5-Benzoyl-1-(4-methoxy-phenyl)-4-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-ethanone 

Relevant academic research and scientific papers

Bis-heterocycles. Part I: Tetrahydro-5,5′- bi(1,2,4-triazin-6-ones)

Selected sets of tetrahydro-5,5′-bi(1,2,4-triazines) (1-3) appended with acetyl, benzoyl, and ester moieties at C-3 position and N-1 (p-substituted)phenyl ring have been prepared and characterized by spectral (IR, NMR, MS) data and X-ray diffraction for c

Spectral characterization, CT-DNA binding, DFT/B3LYP, molecular docking and antitumor studies for new nano-sized VO(II)-hydrazonoyl complexes

New hydrazonoyl chloride derivatives were prepared and characterized. Their VO(II) complexes were isolated after adjusting reaction medium to slightly basic by 0.5?g acetate. Neutral tridentate mode is a general coordination feature of ligands towards bin

Synthesis, in vitro and in Silico studies of some novel 5-nitrofuran-2-yl hydrazones as antimicrobial and antitubercular agents

In this study, we synthesized two series of novel 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e in addition to a third series of thiophene-2-carbohydrazides 23a-g to develop potent antimicrobial and/or antitubercular agents. The newly synthesized compounds were evaluated in vitro for their antimicrobial and antimycobacterial activities. Most of the 5-nitrofuran-2-carbohydrazides 21a-h and 22a-e displayed variable activity against Aspergillus fumigates, Staphylococcus aureus, Streptococcus pneumonia, Bacillis subtilis, Salmonella typhimurium, Klebsiella pneumonia, Escherichia coli and Mycobacterium tuberculosis. The sulfonamide derivative 21f exhibited superior potency and broad-spectrum antimicrobial activity with minimum inhibitory concentration (MIC)=0.06-0.98 μg/mL and antimycobacterial activity with MIC=3.9 μg/mL. The 5-nitrofuran-2-carbohydrazides 21a, b, g, h and 22a-c exhibited significant antibacterial activity with MIC values in the range of 0.12-7.81 μg/mL. The significances of the 5-nitrofuran moiety and sulfonamide function were explored via the structure-activity relationship (SAR) study. In addition, docking studies revealed that the p-amino benzoic acid (PABA) and binding pockets of the dihydropteroate synthase (DHPS) were successfully occupied by compound 21f. Furthermore, two quantitative structure-activity relationship (QSAR) models were built to explore the structural requirements which controlled the activity.

METHODS OF TREATING OR PREVENTING CARDIAC ARRHYTHMIA

This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K+ current (IKur) of the human atrium in a use-dependent and/or rate dependent m

Efficient synthesis of 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones

A novel process and intermediates thereof for making 4,5-dihydro-pyrazolo[3,4-c]pyrid-2-ones of the type shown below from appropriate phenyl hydrazines is described. These compounds can be useful as factor Xa inhibitors.

HETEROCYCLES FROM NITRILE IMINES. PART IV. CHIRAL 4,5-DIHYDRO-1,2,4-TRIAZIN-6-ONES

The reaction of nitrile imines (II) with α-amino esters (III) proceeds with no detectable racemization and constitutes a convenient synthetic route to 4,5-dihydro-1,2,4-triazin-6-ones (IV).Permangamate oxidation of heterocycles (IV) affords the corresponding 1,2,4-triazin-6-ones (V).The reaction of (II) with β-amino esters gives the respective acyclic amidrazone adducts (VI).