5689-71-4

Basic information

• Product Name: 2-(4-methoxyphenyl)-1,3-dioxane
• CAS NO: 5689-71-4
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.2271
• Mol File: 5689-71-4.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 302.6°C at 760 mmHg
• Flash Point: 100.8°C
• Density: 1.099g/cm³
• Vapor Pressure: 0.00176mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: 2-(4-methoxyphenyl)-1,3-dioxane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)-1,3-dioxane(5689-71-4)
• EPA Substance Registry System: 2-(4-methoxyphenyl)-1,3-dioxane(5689-71-4)

Safety Data

• Hazardous Substances Data: 5689-71-4(Hazardous Substances Data)

Usage

Physical state

Colorless liquid.

Odor

Faint, sweet.

Usage

Commonly used as a fragrance ingredient in perfumes and cosmetics.

Synthesis

Synthesized by the reaction of 4-methoxyphenyl lithium with ethyl chloroacetate, followed by cyclization and subsequent hydrolysis.

Stability

Relatively stable and non-reactive under normal conditions.

Safety precautions

May cause skin and eye irritation upon contact and should be handled with care.

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 504-63-2 trimethyleneglycol 
• 22391-03-3 2-(4-methoxyphenyl)-1,3-oxathiolane 
• 24588-72-5 2-(4-methoxyphenyl)-1,3-dithiane 
• 2186-92-7 p-Anisaldehyde dimethyl acetal 
• 627-30-5 1-chloro-3-hydroxypropane 
• 17887-80-8 1,3-bis(trimethylsiloxy)propane 
• 135362-69-5 3-(4-methoxybenzyl)oxypropan-1-ol 

Downstream Products

• 22865-60-7 1-(4-methoxybenzyl)-4-methylbenzene 
• 53039-51-3 1-(4-methoxybenzyl)-3-methylbenzene 
• 53039-52-4 1-methyl-2-(4-methoxybenzyl) benzene 
• 504-63-2 trimethyleneglycol 
• 794527-59-6 (2R,3S)-3-[2-(4-Methoxy-benzyloxy)-ethyl]-oxirane-2-carbaldehyde 
• 146986-42-7 ((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl) oxiran-2-yl)methanol 
• 158817-21-1 (E)-5-(4-methoxybenzyloxy)pent-2-en-1-ol 
• 1376666-04-4 C₂₃H₂₅F₃O₆ 
• 1376666-17-9 C₂₆H₄₂O₅Si 
• 1376666-15-7 C₂₂H₃₆O₄Si 
• 1376666-13-5 C₂₂H₃₈O₄Si 
• 1376666-11-3 (4R,5S,E)-ethyl-5-hydroxy-7-(4-methoxybenzyloxy)-4-methylhept-2-enoate 
• 1005776-31-7 (E)-ethyl-3-((2S,3S)-3-(2-(4-methoxybenzyloxy)ethyl)oxiran-2-yl)acrylates 
• 158817-23-3 (2R,3R)-5-p-methoxybenzyloxy-3-methylpentane-1,2-diol 

Relevant articles and documents

A Direct Method for the Efficient Synthesis of Benzylidene Acetal at Room Temperature

For the first time, a metal-free direct method has been developed for the efficient synthesis of benzylidene acetal at room temperature using Dowex 50WX8 as a solid acid catalyst and Cl3CCN as a novel water scavenger. At room temperature, a wide variety of aryl and α,β-unsaturated aldehydes react readily with functionalized 1,2- and 1,3-diols to furnish the corresponding acetals in very good yields. Labile functional groups, like N-Boc, N-Cbz, -OTBDMS, -OBn, -N3 and acetonide are found to be stable under the reaction conditions. The versatility of this method is further demonstrated with carbohydrate substrates and optically active diols.

Cyclopentyl methyl ether-NH4X: A novel solvent/catalyst system for low impact acetalization reactions

Cyclopentyl methyl ether, a low impact ether forming a positive azeotrope with water, was successfully employed as a solvent in the synthesis of 1,3-dioxanes and 1,3-dioxolanes carried out under Dean-Stark conditions by the acetalization of aliphatic and aromatic aldehydes or ketones, employing ammonium salts as environmentally friendly acidic catalysts.

Synthesis of 2-R-1,3-dioxanes, derivatives of functionally substituted aldehydes of vanillin series

By the condensation of substituted aldehydes of vanillin series with 1,3-propanediol in boiling benzene in the presence of sulfo cation exchanger FIBAN K-1 as catalyst functionally 2-R-substituted 1,3-dioxanes were synthesized.