56917-40-9Relevant academic research and scientific papers
Synthesis and evaluation of 1,2,4-methyltriazines as mGluR5 antagonists
Olson, Jeremy P.,Gichinga, Moses G.,Butala, Elizabeth,Navarro, Hernan A.,Gilmour, Brian P.,Carroll, F. Ivy
, p. 4276 - 4286 (2011/07/29)
In previous studies we showed that 3-(substituted phenylethynyl)-5- methyl[1,2,4]triazine analogues of MPEP were potent antagonists of glutamate-mediated mobilization of internal calcium in an mGluR5 in vitro efficacy assay. In the present study we report
Process for producing ethynylbenzenes
-
, (2008/06/13)
There is disclosed a novel process for preparing anti-inflammatory ethynylbenzene derivatives represented by the general formula I: STR1 wherein Y is hydrogen, halogen or loweralkyl of 1 to 3 carbon atoms; R represents a ring having the structure: STR2 wherein x is 1 to 3, or a ring of the structure: STR3 wherein Y' is hydrogen, halogen, loweralkyl of 1 to 3 carbon atoms and loweralkoxy of 1 to 3 carbon atoms; Y" is hydrogen or halogen; and Y"' is hydrogen or halogen, provided Y, Y', Y" and Y"' are not all hydrogen at the same time, by reacting a benzyl alcohol of formula V: STR4 with a sulfonyl chloride, reducing the sulfonate VI of the formula: STR5 and dehydrohalogenating the formed β-halostyrene of the formula VII: STR6
