5692-26-2

Basic information

• Product Name: Benzamide, N-(cyanophenylmethyl)-
• CAS NO: 5692-26-2
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 5692-26-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzamide, N-(cyanophenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, N-(cyanophenylmethyl)-(5692-26-2)
• EPA Substance Registry System: Benzamide, N-(cyanophenylmethyl)-(5692-26-2)

Safety Data

• Hazardous Substances Data: 5692-26-2(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 10374-29-5 N-benzylidenebenzamide 
• 53641-60-4 2-phenylglycinonitrile hydrochloride 
• 532-28-5 (RS)-mandelonitrile 

Downstream Products

• 113059-19-1 (2-chloro-benzylidene)-(2,4-diphenyl-oxazol-5-yl)-amine 
• 934235-75-3 tert-butyl 2,4-diphenyloxazol-5-ylcarbamate 
• 137102-04-6 1-(2-Benzylamino-2-phenyl-ethyl)-3-(2,6-diisopropyl-phenyl)-urea 
• 137101-99-6 (+/-)-N-<2-<<<<2,6-bis(1-methylethyl)phenyl>amino>carbonyl>amino>-1-phenylethyl>benzenecarboxamide 
• 137102-00-2 (+/-)-N-(2-amino-1-phenylethyl)benzamide 
• 17960-26-8 2,4-diphenyl-oxazol-5-ylamine 
• 784078-61-1 2,4-diphenyl-oxazol-5-ylamine 
• 22427-84-5 benzylidene-(2,4-diphenyl-oxazol-5-yl)-amine 
• 32512-67-7 (R)-2-acetylamino-1-benzamino-1-phenyl-ethane 

Relevant articles and documents

Enantioselective hydrocyanation of N-protected aldimines

Enantioselective hydrocyanation of N-benzyloxycarbonyl aldimines catalyzed by a Ru[(S)-phgly]2[(S)-binap]/C6H5OLi system or a bimetallic complex [Li{Ru[(S)-phgly]2[(S)-binap]}]Cl affords the amino nitriles in 92 - 99% ee. The reaction is carried out in tert-C 4H9OCH3 with a substrate-to-catalyst molar ratio in the range of 500 - 5000 at -20 to 0°C. Primary, secondary, and tertiary alkyl imines as well as the aryl and heteroaryl substrates are smoothly cyanated to produce the desired products in high yield.

Inhibitors of acyl-CoA:cholesterol O-acyl transferase (ACAT) as hypocholesterolemic agents. 8. Incorporation of amide or amine functionalities into a series of disubstituted ureas and carbamates. Effects of ACAT inhibition in vitro and efficacy in vivo

A series of disubstituted ureas containing amide or amine groups was prepared and evaluated for their ability to inhibit acyl-CoA:cholesterol O- acyl transferase in vitro and to lower plasma total cholesterol in a variety of cholesterol-fed rat models in vivo. The presence of polar or ionizable functionalities within this class of compounds may impart greater aqueous solubility to those compounds and thus allow improved transport to the enzyme location within the intestinal enterocyte. Compounds from this class exhibit good cholesterol lowering in a chronic cholesterol-fed rat model of hypercholesterolemia even when dosed in an aqueous vehicle. In general, the amine-containing compounds were more potent and efficacious than the amides in the acute rat model of hypercholesterolemia. Further structure-activity relationship studies showed that the preferred position of the amide/amine group was β to the urea moiety and not α, and that in this series, the presence of a secondary amine (or amide) proton is required for good in vitro potency. One of these compounds, 9n(-), lowered plasma total cholesterol (- 47%) and elevated high-density lipoprotein cholesterol (+256%) when dosed in an aqueous vehicle to rats with preestablished hypercholesterolemia.