56921-85-8

Usage

Uses

Used in Pharmaceutical Industry:
2-(4-Bromo-phenyl)-imidazo[1,2-a]pyrimidine is utilized as a key intermediate in the synthesis of various biologically active compounds, primarily for the development of drugs. Its role in drug development is crucial due to its potential in treating a range of diseases, including cancer, inflammation, and infectious diseases.
Used in Drug Development for Cancer Treatment:
In the field of oncology, 2-(4-Bromo-phenyl)-imidazo[1,2-a]pyrimidine is employed as a precursor for the creation of anticancer agents. Its unique molecular structure allows for the design of drugs that can target specific pathways and mechanisms within cancer cells, potentially leading to more effective treatments with fewer side effects.
Used in Drug Development for Inflammatory Conditions:
2-(4-Bromo-phenyl)-imidazo[1,2-a]pyrimidine is also used as a building block for developing drugs aimed at treating inflammatory conditions. Its structure may facilitate the design of anti-inflammatory agents that can modulate immune responses and reduce inflammation more effectively.
Used in Drug Development for Infectious Diseases:
2-(4-Bromo-phenyl)-imidazo[1,2-a]pyrimidine is further applied in the development of drugs to combat infectious diseases. Its potential to be incorporated into antimicrobial, antiviral, or antiparasitic agents could contribute to the creation of new therapies to address current and emerging infectious threats.
Used in Agrochemicals:
Beyond human medicine, 2-(4-Bromo-phenyl)-imidazo[1,2-a]pyrimidine may also find use in the agrochemical industry. Its application could be in the development of pesticides or other agricultural chemicals that can protect crops from pests and diseases, thereby increasing agricultural productivity.
Used in Materials Science:
In the realm of materials science, the compound's unique properties might be harnessed for the development of new materials with specific characteristics, such as improved stability, reactivity, or other desirable traits for various industrial applications.

InChI:InChI=1S/C12H8BrN3/c13-10-4-2-9(3-5-10)11-8-16-7-1-6-14-12(16)15-11/h1-8H

Upstream product

• 109-12-6 2-aminopyrimidine 
• 99-73-0 para-bromophenacyl bromide 
• 875289-82-0 2,4-dinitro-benzenesulfonic acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 
• 99-90-1 para-bromoacetophenone 
• 98475-05-9 α-tosyloxy-4-bromoacetophenone 

Downstream Products

• 64454-32-6 2-(4-bromo-phenyl)-3-nitroso-imidazo[1,2-a]pyrimidine 
• 143696-99-5 2-(4-Bromo-phenyl)-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrimidine 
• 60472-19-7 5-(p-bromophenyl)-2-aminoimidazole 
• 60472-19-7 4-(4-bromophenyl)-1H-imidazol-2-ylamine 
• 134044-60-3 2-(4-Bromo-phenyl)-3-nitro-imidazo[1,2-a]pyrimidine 
• 134044-61-4 2-(4-Bromo-phenyl)-imidazo[1,2-a]pyrimidin-3-ylamine 

Relevant academic research and scientific papers

DIAZABICYCLIC SUBSTITUTED IMIDAZOPYRIMIDINES AND THEIR USE FOR THE TREATMENT OF BREATHING DISORDERS

The present invention relates to novel diazabicyclically substituted imidazo[1,2-a]pyrimidine derivatives, to methods for producing the same, to the use thereof either alone or in combinations for the treatment and/or prevention of diseases, as well as to

NOVEL COMPOUND WITH ELECTRON INJECTION AND/OR ELECTRON TRANSPORT CAPABILITIES AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

A compound represented by Formula 1 below and an organic light-emitting device including the compound are provided: Formula 1 Substituents in Formula 1 are the same as defined in the specification.

Imidazo[1,2-A]pyrimidine-containing compounds, method for preparing the same, and their use in electronic devices

The present disclosure describes novel imidazo[1,2-a]pyrimidine-containing organic light-emitting compounds represented by formula (I): wherein R1 and R2 independently represent hydrogen, an alkyl group, or an aryl group which is uns

Structure-activity relationship of 4(5)-aryl-2-amino-1 H -imidazoles, N 1-substituted 2-aminoimidazoles and imidazo[1,2- a ]pyrimidinium salts as inhibitors of biofilm formation by salmonella typhimurium and pseudomonas aeruginosa

A library of 112 4(5)-aryl-2-amino-1H-imidazoles, 4,5-diphenyl-2-amino-1H- imidazoles, and N1-substituted 4(5)-phenyl-2-aminoimidazoles was synthesized and tested for the antagonistic effect against biofilm formation by Salmonella Typhimurium and Pseudomo

Hypervalent iodine(III) sulfonate mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines in liquid PEG-400

PEG-400[poly(ethylene glycol-400)] is used as a "green" recyclable solvent in the one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines by reaction with ketones, [hydroxyl(2,4-dinitrobenzenesulfonyloxy)-iodo]benzene (HDNIB), and 2-aminopyrimidine. Signific

Imidazopyrimidine-based compound and organic light-emitting device employing organic layer including the same

lmidazopyrimidine-based compounds represented by Formula and organic light-emitting devices employing organic layers including the imidazopyrimidine-based compounds are provided. Organic light-emitting devices employing organic layers including the imidazopyrimidine-based compounds feature low driving voltages, high efficiency, high brightness, long lifetimes, and low power consumption.

A facile [hydroxy(tosyloxy)iodo]benzene mediated synthesis of 2-arylimidazo[1,2-a]pyrimidines and their conversion into 3-bromo-2- arylimidazo[1,2-a]pyrimidines

α-Tosyloxyketone 2, obtained through hypervalent iodine oxidation of enolizable ketones using [hydroxy(tosyloxy)iodo]benzene (HTIB) in acetonitrile, on treatment with 2-aminopyrimidine 3 generates regioselectively 2-arylimidazo[1,2-a]pyrimidine 6 which up

Organic reactions in ionic liquids: Ionic liquid-accelerated one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines

The room-temperature ionic liquid n-butylpyridinium tetrafluoroborate (BPyBF4) is used as a recyclable alternative to classical molecular solvents in the one-pot synthesis of 2-arylimidazo[1,2-a]pyrimidines by reaction with ketones, [hydroxy(tosyloxy)iodo]benzene, and 2-aminopyrimidine. Significant rate enhancements and improved yields have been observed. Copyright Taylor & Francis, Inc.

Synthesis of bridgehead nitrogen heterocycles on a solid surface

Bridgehead nitrogen heterocycles were synthesized from heteroaromatic amidines and cyclic or acyclic α-bromoketones under solvent-free conditions at room temperature on a solid surface in excellent yields, which are higher than those obtained with hithert

NITROGENOUS HETEROCYCLIC DERIVATIVE AND ORGANIC ELECTROLUMINESCENT ELEMENT EMPLOYING THE SAME

A specific derivative of heterocyclic compound having nitrogen atom and an organic electroluminescence device comprising the compound. An organic electroluminescence device comprising at least one of organic compound layers including a light emitting layer sandwiched between an anode and a cathode, wherein said at least one of the organic compound layers comprises the derivative of the heterocyclic compound having nitrogen atom as a sole component or as mixed component. The organic electroluminescence device achieves elevation of luminance and excellent efficiency of light emission, and also achieves long lifetime by an improvement of an electrode adhesion.