56934-87-3

Usage

Uses

Used in Pharmaceutical Industry:
3,5-DIMETHYLISATOIC ANHYDRIDE is used as a building block for the synthesis of various drugs and compounds, contributing to the development of new pharmaceutical products.
Used in Chemical Industry:
3,5-DIMETHYLISATOIC ANHYDRIDE is used as a reagent in organic reactions and as a precursor for the preparation of various organic compounds, facilitating the advancement of chemical research and development.
Used in Research and Development:
3,5-DIMETHYLISATOIC ANHYDRIDE is utilized in research and development efforts to explore its potential applications and properties, furthering the understanding of its role in the pharmaceutical and chemical industries.

InChI:InChI=1/C10H9NO3/c1-5-3-6(2)8-7(4-5)9(12)14-10(13)11-8/h3-4H,1-2H3,(H,11,13)

Upstream product

• 124-38-9 carbon dioxide 
• 201230-82-2 carbon monoxide 
• 4102-54-9 2-iodo-4,6-dimethylaniline 

Downstream Products

• 56934-54-4 2-Amino-3,5-dimethylbenzamide 
• 343855-78-7 2-amino-3,5-dimethylbenzohydrazide 

Relevant academic research and scientific papers

Palladium-Catalyzed Cyclization Reaction of o-Iodoanilines, CO2, and CO: Access to Isatoic Anhydrides

Isatoic anhydrides, a class of valuable synthetic intermediates and RNA structure probing reagents, are usually prepared with highly toxic phosgene or stoichiometric oxidants. Herein we report a highly selective palladium-catalyzed cyclization reaction for the efficient synthesis of isatoic anhydrides from readily available o-iodoanilines, CO2, and CO. The reaction proceeds under mild conditions and is redox-neutral. Both CO2 and CO are indispensable C1 building blocks for this catalytic reaction.

Palladium-catalyzed carbonylation of o-iodoanilines for synthesis of isatoic anhydrides

A novel palladium-catalyzed oxidative double carbonylation of o-iodoanilines for the synthesis of isatoic anhydrides has been developed. The reaction employs readily available o-iodoanilines as the starting materials and proceeds under mild conditions. For extension, palladium-catalyzed oxidative carbonylation of anthranilic acids was developed for the synthesis of substituted isatoic anhydrides in high to excellent yields.

Antisecretory oxamic acid esters

Variously substituted oxanilic acid esters possessing anti-secretary activity are useful anti-ulcer agents.

Oxanilic acids, a new series of orally active antiallergic agents

A large number of oxanilic acid esters and N heteroaryl oxamic acid esters were prepared and found to have antiallergic activity using the rat passive cutaneous anaphylaxis (PCA) test. Many of the oxanilic acid esters are active orally, with the most active species having an aryl 2' carbamoyl group and a 3' methoxy group. Hydrolysis of the ester from the oxanilic ester moiety causes a loss of oral activity.