56946-83-9

Basic information

• Product Name: 2,5-Dichlorothiophene-3-sulfonyl chloride
• Synonyms: 2,5-DICHLOROTHIOPHENE-3-SULFONYL CHLORIDE;2,5-DICHLOROTHIOPHENE-3-SULPHONYL CHLORIDE;AKOS 93404;BUTTPARK 27\06-19;2,5-DICHLOROTHIOPHENE-3-SULFONYL CHLORID;2,5-Dichloro-3-Thiophene Sulfonel Chloride;2,5-DICHLORO-3-THIOPHENE SULFONYL CHLORIDE;3-THIOPHENESULFONYLCHLORIDE,2,5-DICHLORO
• CAS NO: 56946-83-9
• Molecular Formula: C₄HCl₃O₂S₂
• Molecular Weight: 251.54
• Product Categories: Thiophene&Benzothiophene;Halogenated Heterocycles;Heterocyclic Building Blocks;Thiophenes;ThiophenesBuilding Blocks
• Mol File: 56946-83-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 130 °C
• Boiling Point: 256-257 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.697 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.000523mmHg at 25°C
• Refractive Index: n20/D 1.595(lit.)
• Storage Temp.: 2-8°C
• Sensitive: Moisture Sensitive
• BRN: 1285315
• CAS DataBase Reference: 2,5-Dichlorothiophene-3-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Dichlorothiophene-3-sulfonyl chloride(56946-83-9)
• EPA Substance Registry System: 2,5-Dichlorothiophene-3-sulfonyl chloride(56946-83-9)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 1760 8/PG 3
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 56946-83-9(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

2,5-Dichlorothiophene-3-sulfonyl chloride may be used in the preparation of:1-[(2,5-dichloro-3-thienyl)sulfonyl]-N-(6-nitro-1,3-benzothiazol-2-yl)piperidine-4-carboxamide6-chloro-3-isopropylamino-4H-thieno[2,3-e]-1,2,4-thiadiazine 1,1-dioxide6-fluoro-3-methyl-4-(2,5-dichlorothiophene-3-sulfonyl)-3,4-dihydroquinoxalin-2-(1H)-one

General Description

2,5-Dichlorothiophene-3-sulfonyl chloride is an heteroaryl sulfonyl chloride derivative.

InChI:InChI=1/C4HCl3O2S2/c5-3-1-2(4(6)10-3)11(7,8)9/h1H

Upstream product

• 3172-52-9 2,5-diclorothiophene 

Downstream Products

• 1096925-38-0 4-{[(2,5-dichlorothiophen-3-yl)sulfonyl]amino}-2-hydroxybenzoic acid 
• 1448334-90-4 1-(2,5-dichloro-thiophene-3-sulfonyl)-4-[5-(4-methoxyphenyl)-[1,3,4]oxadiazol-2-yl]piperazine 
• 1365699-65-5 4β-[2,5-dichlorothiophene-3-sulfonamido]podophyllotoxin 
• 53595-68-9 2,5-dichloro-3-thiophenesulfonamide 
• 59768-12-6 2,5-dichloro-4-nitrothiophene-3-sulfonyl Chloride 

Relevant articles and documents

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

Phenylenediamine urotensin-II receptor antagonists and CCR-9 antagonists

The present invention relates to urotensin II receptor antagonists, CCR-9 antagonists, pharmaceutical compositions containing them and their use.

Fungicidal sulfonamidothiophenes

Novel thiophenes of the formula STR1 wherein X and Z individually are nitro, fluoro, chloro or bromo, Y is hydrogen, nitro, fluoro, chloro or bromo, R1 is alkyl or aryl and R2 is hydrogen or haloalkylthio, are useful for the prevention or cure of fungal infections.