3172-52-9Relevant articles and documents
2, 5-dichloro thiophene preparation method
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Paragraph 0021; 0022, (2016/12/12)
The present invention discloses a 2, 5-dichloro thiophene preparation method comprising the following steps: (1) an organic solvent and thiophene are added into a reaction vessel and warmed to reflux, under reflux conditions, batches of added N-chlorosucc
Synthesis and structural characterization of 2,5-dihalo-3,4- dinitrothiophenes
Wen, Li,Rasmussen, Seth C.
, p. 387 - 398 (2008/02/05)
Using new nitration protocols, we have been able to efficiently dinitrate 2,5-dihalothiophenes with yields of ~80-95%. The resulting products 2,5-dibromo-3,4-dinitrothiophene (1), 2,5-dichloro-3,4-dinitrothiophene (2), 2-bromo-5-chloro-3,4-dinitrothiophene (3), as well as the analogous 2-bromo-3,4-dinitrothiophene (4), all crystallize easily allowing their characterization via X-ray crystallography. Crystallization of 1 occurs in the monoclinic space group C2/c with a=14.547(3)A, b=7.3534(15)A, c=10.775(2)A, β=128.89(3)°, and Z=4. Crystallization of 2 occurs in the tetragonal space group I-42d with a=9.9398(14)A, b=9.9398(14)A, c=16.866(3)A, and Z=8. Crystallization of 3 occurs as a pseudo-merohedral twin in the triclinic space group P-1 with a=7.340(5)A, b=8.094(5)A, c=9.112(5)A, α=82.059(5)°, β=66.232(5)°, γ=63.021(5)°, and Z=2. Crystallization of 4 occurs in the triclinic space group P-1 with a=7.1787(14)A, b=7.4092(15)A, c=8.3151(17)A, α=101.67(3)°, β=96.00(3)°, γ=116.13(3)°, and Z=2. The structures of all compounds exhibit the formation of interesting solid-state assemblies due to halogen-bonding interactions between the halogen and nitro groups. Springer Science+Business Media, LLC 2007.
Chlorinated thiophenes. Part 2. Trihalogenated hydroxythiophenes; preparation, reactions and tautomeric properties
Skramstad, Jan,Lunde, Andreas,Hope, Hakon,Bjornstad, Vidar,Froyen, Paul
, p. 1453 - 1458 (2007/10/03)
2-Hydroxy-3,4,5-trichlorothiophene (4), 3-hydroxy-4-bromo-2,5-dichlorothiophene (5) and 3-hydroxy-2,4,5-trichlorothiophene (6) have been synthesised. It was found that 4 exists in a carbonyl form, whereas 5 and 6 the hydroxy forms were the major tautomers