56952-05-7

Upstream product

• 15964-81-5 methyl 3-hydroxy-4-methoxyphenylacetate 
• 81038-45-1 2-bromo-5-hydroxy-4-methoxyphenyl-acetonitrile 
• 4468-58-0 3-hydroxy-4-methoxyphenylacetonitrile 
• 1131-94-8 homoisovanillic acid 
• 67-56-1 methanol 
• 81038-48-4 2-bromo-4-methoxy-5-hydroxylphenylacetic acid 

Downstream Products

• 1232402-53-7 (2-bromo-5-difluoromethoxy-4-methoxy-phenyl)-acetic acid methyl ester 
• 58116-06-6 (+/-)-6'-Bromo-N-norreticuline 
• 56522-51-1 2-bromo-5-hydroxy-4-methoxyphenethylamine 
• 862794-30-7 N-(2-bromo-5-hydroxy-4-methoxyphenethyl)-N-(3-bromo-4-hydroxybenzyl)formamide 
• 862794-28-3 2-bromo-5-hydroxy-4-methoxyphenylacetamide 
• 81038-51-9 2-(2-Bromo-5-hydroxy-4-methoxy-phenyl)-N-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-acetamide 

Relevant academic research and scientific papers

Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents

Phenanthrene-based tylophorine-1 (PBT-1) was identified previously as a lead compound in an anticancer drug discovery effort based on natural Tylophora alkaloids. An expanded structural optimization using a new more efficient synthetic route provided 14 P

DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS

Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Galanthamine analogs: 6H-benzofuro[3a,3,2,-e,f][1]benzazepine and 6H-benzofuro[3a,3,2-e,f][3]benzazepine

The known cholinesterase inhibitory capability of the Amarylidaceae alkaloid galanthamine prompted preparation of analogs in which the position of the nitrogen within the azepine ring is altered. The analogs 6H-benzofuro[3a,3,2-e,f][1]benzazepine and 6H-benzofuro[3a,3,2-e,f][3] benzazepine were prepared in 19 and 2.5%, respectively, following Kametani and Shimizu approaches, respectively. The aniline derivative 6H-benzofuro[3a,3,2-e, f][1]benzazepine failed to undergo most of the reactions typical for galanthamine. Thus, it neither oxidized to the analogous narwedine, nor epimerized to the analogous epigalanthamine, nor reduced to the lycoramine analog, under the conditions used for galanthamine.