2-CHLORO-3-HYDROXYBENZALDEHYDE 97

Base Information

• Chemical Name: 2-CHLORO-3-HYDROXYBENZALDEHYDE 97
• CAS No.: 56962-10-8
• Molecular Formula: C7H5 Cl O2
• Molecular Weight: 156.569
• Hs Code.: 2913000090
• Mol file: 56962-10-8.mol

Synonyms:2-Chloro-3-hydroxybenzaldehyde;3-Hydroxy-2-chlorobenzaldehyde

Chemical Property of 2-CHLORO-3-HYDROXYBENZALDEHYDE 97

Chemical Property:

• Vapor Pressure: 0.0188mmHg at 25°C
• Melting Point: 139-143 °C(lit.)
• Boiling Point: 245°C at 760 mmHg
• PKA: 7.77±0.10(Predicted)
• Flash Point: 102°C
• PSA: 37.30000
• Density: 1.404g/cm³
• LogP: 1.85810
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-chloro-3-hydroxy-Benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-37/38-41-50
• Safety Statements: 26-36-60-61

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-chloro-3-hydroxy-Benzaldehyde is a versatile building block used in the preparation of positional isomers of NOSH-aspirin a dual nitric oxide and hydrogen sulfide releasing hybrid pharmaceutical.

Technology Process of 2-CHLORO-3-HYDROXYBENZALDEHYDE 97

There total 5 articles about 2-CHLORO-3-HYDROXYBENZALDEHYDE 97 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

meta-hydroxybenzaldehyde (100-83-4) → 2-chloro-3-hydroxybenzaldehyde (56962-10-8)

Guidance literature:

With 1,3-dichloro-5,5-dimethylhydantoin; diisopropylamine hydrochloride; In toluene; at 0 ℃; for 4h; regioselective reaction; Darkness;

DOI:10.1021/acscatal.8b00327

Reference yield: 42.0%

meta-hydroxybenzaldehyde (100-83-4) → 2-chloro-5-hydroxybenzaldehyde (7310-94-3) + 3-hydroxy-4-chlorobenzaldehyde (56962-12-0) + 2-chloro-3-hydroxybenzaldehyde (56962-10-8)

Guidance literature:

meta-hydroxybenzaldehyde; With toluene-4-sulfonic acid; In water; acetonitrile; at 20 ℃; for 0.0833333h;

With N-chloro-succinimide; In water; acetonitrile; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1016/j.tet.2010.06.041

Reference yield:

tert-butylhypochlorite (507-40-4) + meta-hydroxybenzaldehyde (100-83-4) → 2-chloro-3-hydroxybenzaldehyde (56962-10-8)

Guidance literature:

With acetic acid;

DOI:10.1021/ja01146a061

upstream raw materials:

tert-butylhypochlorite

meta-hydroxybenzaldehyde

Downstream raw materials:

2-Chloro-3-hydroxy benzoic acid

2-chloro-3-(hydroxymethyl)phenol

4-bromo-2-chloro-3-hydroxy-benzaldehyde

4,6-dibromo-2-chloro-3-hydroxy-benzaldehyde