56977-10-7

Basic information

• Product Name: Butanedioic acid, hydroxy-, bis(phenylMethyl) ester
• Synonyms: Butanedioic acid, hydroxy-, bis(phenylMethyl) ester
• CAS NO: 56977-10-7
• Molecular Formula: C₁₈H₁₈O₅
• Molecular Weight: 314.33252
• Mol File: 56977-10-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Butanedioic acid, hydroxy-, bis(phenylMethyl) ester(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic acid, hydroxy-, bis(phenylMethyl) ester(56977-10-7)
• EPA Substance Registry System: Butanedioic acid, hydroxy-, bis(phenylMethyl) ester(56977-10-7)

Safety Data

• Hazardous Substances Data: 56977-10-7(Hazardous Substances Data)

Upstream product

• 617-48-1 malic acid 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 

Downstream Products

• 208037-70-1 2-Trifluoromethanesulfonyloxy-succinic acid dibenzyl ester 
• 208037-93-8 (S)-dibenzyl 2-(1-benzyl-5-(tert-butoxycarbonyl)pyrrolidin-2-ylidene)succinate 
• 208037-71-2 2-[(R)-1-Benzyl-5-tert-butoxycarbonyl-pyrrolidin-(2Z)-ylidene]-succinic acid dibenzyl ester 

Relevant articles and documents

Design, Synthesis, and Activity Study of Water-Soluble, Rapid-Release Propofol Prodrugs

In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clinically) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clinical benefits of propofol. The experimental results showed the potential of such compounds as water-soluble prodrugs of propofol.

THERMOCLEAVABLE FRICTION MODIFIERS AND METHODS THEREOF

Certain embodiments of the invention provide a lubricating oil composition comprising a lubricating oil base stock and a compound of formula (I): or a salt thereof, wherein R1, R2, R3 and R4 have any of the values defined in the specification, as well as methods of use thereof.

Hydrogenolysis of benzyl esters with palladium-on-carbon catalysts.

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