56990-04-6

Basic information

• Product Name: 4,5-dichloro-2-nitrobenzaldehyde
• Synonyms: 4,5-dichloro-2-nitrobenzaldehyde;3,4-Dichloro-6-nitrobenzaldehyde
• CAS NO: 56990-04-6
• Molecular Formula: C₇H₃Cl₂NO₃
• Molecular Weight: 220.00962
• Mol File: 56990-04-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4,5-dichloro-2-nitrobenzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 4,5-dichloro-2-nitrobenzaldehyde(56990-04-6)
• EPA Substance Registry System: 4,5-dichloro-2-nitrobenzaldehyde(56990-04-6)

Safety Data

• Hazardous Substances Data: 56990-04-6(Hazardous Substances Data)

Usage

General Description

4,5-dichloro-2-nitrobenzaldehyde is a chemical compound with the molecular formula C7H4Cl2NO3. It is a yellow crystalline powder and is used as an intermediate in the production of various organic compounds. 4,5-dichloro-2-nitrobenzaldehyde is also utilized in the synthesis of pharmaceuticals and agrochemicals. It has a wide range of applications in the chemical industry due to its ability to undergo various chemical reactions and form different products. It is important to handle this compound with care as it may cause irritation to the skin, eyes, and respiratory system.

Upstream product

• 7494-45-3 1,2-dichloro-4-methyl-5-nitrobenzene 
• 6641-64-1 4,5-dichloro-2-nitroaniline 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 224635-99-8 4,5-dichloro-2-nitrobenzylamine 
• 28523-93-5 4,5-dichloro-2-nitrobenzonitrile 
• 224635-91-0 4,5-dichloro-2-nitrobenzenemethanol 

Downstream Products

• 56988-27-3 C₁₅H₈Cl₃NO₄ 
• 56988-35-3 C₁₅H₇Cl₄NO₄ 
• 175918-54-4 (Z)-5-<(4,5-dichloro-2-nitrophenyl)methylene>imidazolidine-2,4-dione 
• 406500-13-8 5-(4,5-dichloro-2-nitro-phenyl)-3-hydroxy-5H-furan-2-one 
• 406500-21-8 5-(2-amino-4,5-dichloro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester 
• 406500-18-3 5-(4,5-dichloro-2-nitro-phenyl)-4,5-dihydro-1H-pyrazole-3-carboxylic acid methyl ester 
• 175918-55-5 (Z)-5-<(2-amino-4,5-dichlorophenyl)methylene>imidazolidine-2,4-dione 
• 177980-39-1 6,7-dichloro-4-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo<4,5-b>quinolin-2-one 
• 177980-41-5 6,7-dichloro-3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)imidazo<4,5-b>quinolin-2-one 
• 863640-52-2 ethyl(cis,trans)-4,5-dichloro-2-nitro cinnamate 
• 231296-64-3 methyl trans-4,5-dichloro-2-nitrocinnamate 
• 163458-94-4 2-amino-4,5-dichlorobenzaldehyde 
• 1445859-29-9 1-(4,5-dichloro-2-nitrophenyl)prop-2-en-1-one 
• 1445859-33-5 1-cyclopropylcarbonyl-3-(4,5-dichloro-2-nitrophenyl)-4,5-dihydro-1H-pyrazole 

Relevant articles and documents

A General One-Pot Synthesis of 2H-Indazoles Using an Organophosphorus–Silane System

A simple and direct approach for the regioselective construction of the privileged 2H-indazole scaffold is described. The developed one-pot strategy involves phospholene-mediated N?N bond formation to access 2H-indazoles. The amount of organophosphorus reagent was minimized by recycling the phospholene oxide with organosilane reductants. Starting from functionalized 2-nitrobenzaldehydes and primary amines, a mild reductive cyclization, involving the use of commercially available phospholene oxide and silanes, delivered a wide variety of substituted 2H-indazoles in good to excellent yields.

COVALENT INHIBITORS OF KRAS G12C

Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.

Synthesis and biological evaluation of 4,5-dihydro-1H-pyrazole derivatives as potential nNOS/iNOS selective inhibitors. Part 2: Influence of diverse substituents in both the phenyl moiety and the acyl group

In a preliminary article, we reported a series of 4,5-dihydro-1H-pyrazole derivatives as neuronal nitric oxide synthase (nNOS) inhibitors. Here we present the data about the inhibition of inducible nitric oxide synthase (iNOS) of these compounds. In gener