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Usage

Uses

Used in Pharmaceutical Industry:
3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one is used as a pharmaceutical agent for its neuromodulatory properties. As a GABAA antagonist, it can help in the treatment of neurological disorders and conditions related to the central nervous system. Its ability to increase neurogenesis in the hippocampus suggests potential applications in the treatment of neurodegenerative diseases and cognitive impairments.
Used in Steroid Hormone Research:
In the field of endocrinology and steroid hormone research, 3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one serves as a valuable compound for studying the biosynthesis and regulation of various steroid hormones. Its role as a prohormone makes it an essential component in understanding the complex interplay between different hormones and their effects on the body.
Used in Drug Metabolism Studies:
3-beta,17-alpha-dihydroxy-5-alpha-pregnan-20-one is used as a research tool in drug metabolism studies, particularly in the investigation of cytochrome P 450-3A, a major enzyme involved in the metabolism of various drugs and substances. Understanding its modulation of this enzyme can provide insights into drug interactions and the development of more effective therapies.

InChI:InChI=1/C21H34O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h14-18,23-24H,4-12H2,1-3H3/t14-,15-,16+,17-,18-,19-,20-,21-/m0/s1

Upstream product

• 93-59-4 Perbenzoic acid 
• 67-66-3 chloroform 
• 17921-48-1 5β-pregnene-(17(20)t)-diyl-(3β.20)-diacetate 
• 1080507-42-1 5β-pregnene-(17(20)c)-diyl-(3β.20)-diacetate 
• 6003-22-1 3β,21-diacetoxy-5α-pregnan-17α-ol-20-one 
• 102874-41-9 (20Ξ)-3β-acetoxy-20-acetylamino-17,20-epoxy-5α-pregnane 
• 906-83-2 pregnenolone acetate 
• 516-55-2 isopregnanolone 
• 64-17-5 ethanol 
• 79417-82-6 16β-bromo-3β,17-dihydroxy-5α-pregnan-20-one 
• 57-83-0 Progesterone 
• 110-86-1 pyridine 
• 10025-87-3 trichlorophosphate 
• 56909-68-3 3β-acetoxy-20-acetylamino-5α-pregn-17(20)ξ-ene 

Downstream Products

• 5456-44-0 3β-acetoxy-17-hydroxy-5α-pregnan-20-one 

Relevant academic research and scientific papers

5 α-pregnan-20-ones and 5-pregnen-20-ones and related compounds

Compounds of the formulae: STR1 useful as anti-obesity, anti-diabetic, anti-coronary and hypolipidemic agents.

17-Hydroxy-steroids

Compounds of the formulae: STR1 are useful as anti-cancer, anti-obesity, anti-diabetic, anti-coronary agents, anti-aging agents, anti-hypolipidemic agents and anti-autoimmune agents.

The Reaction of Enols with Superoxide Anion Radicals: Preparation of Tertiary α-Ketols

Pregnan-20-ones (1) and (4) and 3β-hydroxy-5α-cholestan-6-one (7) react with KO2 and 18-crown-6 benzene solution and under an oxygen atmosphere at 6-7 deg C to give the corresponding α-hydroperoxides (2), (5), and (8) which after treatment with Ph3P gives α-ketols (3), (6), and (9) in good yields.

STUDY OF THE DIRECT EFFECT OF LHRH AGONIST ON TESTICULAR 17-HYDROXYLASE AND 5α-REDUCTASE ACTIVITIES IN NON-HYPOPHYSECTOMIZED ADULT RATS TREATED WITH AN ANTI-LUTEINIZING HORMONE SERUM

In order to study both direct and pituitary-mediated mechanisms of action of the LHRH analogue 6, des-Gly-NH210>LHRH ethylamide upon testicular steroidogenesis in adult rat, we compared the effects of the agonist when administered alone or concomitantly with an anti-LH serum to non-hypophysectomized rats.Testicular steroid contents and in vitro progesterone and testosterone metabolism were determined.Anti-LH serum administration was able to prevent 5α-reductase stimulation by the agonistic peptide, but not the inhibition of 17-hydroxylase activity.These data suggest that modulation of 17-hydroxylase involves both direct and pituitary-mediated processes, while 5α-reductase stimulation is mainly if not only due to a pituitary-mediated mechanism.

REARRANGEMENT SPINAL DU DIMETHYL-4,4 EPOXY-6α,20α(5α)ANDROSTANE AVEC LE TRICHLORURE DE BORE

A backbone rearrangement of 4,4 dimethyl 6α,20α epoxy (5α)androstane with BCl3 is described.The structures of the resulting compounds have been elucidated either by synthesis from 3β-acetoxy (5α)pregnane 20-one, or by X rays diffraction.