57023-90-2

Basic information

• Product Name: 2-Furancarboxaldehyde, 5-(4-aminophenyl)-
• CAS NO: 57023-90-2
• Molecular Formula: C11H9NO2
• Molecular Weight: 187.198
• Mol File: 57023-90-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Furancarboxaldehyde, 5-(4-aminophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Furancarboxaldehyde, 5-(4-aminophenyl)-(57023-90-2)
• EPA Substance Registry System: 2-Furancarboxaldehyde, 5-(4-aminophenyl)-(57023-90-2)

Safety Data

• Hazardous Substances Data: 57023-90-2(Hazardous Substances Data)

Usage

Description

2-Furancarboxaldehyde, 5-(4-aminophenyl)is a heterocyclic aldehyde derivative of furfural, characterized by its pale yellow solid appearance and a melting point of 161-163°C. With a molecular formula of C11H9NO2, this chemical compound is soluble in organic solvents and is commonly found in various foods and plants. It serves as a starting material in organic synthesis and is recognized for its potential biological activities, such as anticancer and antimicrobial properties, making it a valuable subject in research and scientific studies related to pharmaceutical and medicinal applications.

Uses

Used in Pharmaceutical and Medicinal Research:
2-Furancarboxaldehyde, 5-(4-aminophenyl)is utilized as a starting material in organic synthesis for the development of pharmaceutical compounds. Its potential biological activities, including anticancer and antimicrobial properties, make it a promising candidate for the creation of new drugs and therapies.
Used in Scientific Studies:
This chemical compound is also employed in various scientific studies aimed at understanding its pharmaceutical and medicinal properties further. Research in this area can lead to the discovery of new applications and uses for 2-Furancarboxaldehyde, 5-(4-aminophenyl)-, expanding its relevance in the scientific community.

Upstream product

• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 89415-43-0 (4-aminophenyl)boronic acid 
• 98-01-1 furfural 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 540-37-4 p-aminoiodobenzene 
• 7147-77-5 5-(4-nitrophenyl)-2-furaldehyde 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 106-50-3 1,4-phenylenediamine 

Downstream Products

• 765938-04-3 3-[5-(4-amino-phenyl)-furan-2-yl]-N-[3-benzoyl-4-(2-p-tolyl-acetylamino)-phenyl]-acrylamide 

Relevant articles and documents

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Protein arginine methyltransferase 5 (PRMT5) is an important protein arginine methyltransferase that catalyzes the symmetric dimethylation of arginine resides on histones or non-histone substrate proteins. It has been thought as a promising target for many diseases, particularly cancer. Despite the potential applications of PRMT5 inhibitors in cancer treatment, very few of PRMT5i have been publicly reported. In this investigation, virtual screening and structure–activity relationship studies were carried out to discover novel PRMT5i, which finally led to the identification of a number of new PRMT5i. The most active compound, P5i-6, exhibited a considerable inhibitory potency against PRMT5 with an IC50 value of 0.57?μm, and a high selectivity for PRMT5 against other tested PRMTs. It displayed a very good antiviability activity against two colorectal cancer cell lines, HT-29 and DLD-1, and one hepatic cancer cell line, HepG2, in a sensitivity assay against 36 different cancer cell lines. Western blot assays indicated that P5i-6 selectively inhibited the symmetric dimethylations of H4R3 and H3R8 in DLD-1 cells. Overall, P5i-6 could be used as a chemical probe to investigate new functions of PRMT5 in biology and also served as a good lead compound for the development of new PRMT5-targeting therapeutic agents.

Synthesis and biological evaluation of 2-phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-ones as IKK2 inhibitors

In a search for novel molecules to treat inflammatory disorders, we identified several compounds with inhibitory action against the IKK2 enzyme using in silico methods. Based on the virtual hit of compounds 1 and 2, a novel series of 2-phenylimino-5((5-phenylfuran-2-yl)methylene)thiazolidin-4-one derivatives was designed, synthesized, and evaluated for IKK2 inhibitory activity. Among the synthesized derivatives, compounds 17f and 19f showed good IKK2 inhibitory potency, which have 4-carboxaminophenyl on the 2-furan ring and a methoxy group on the phenylimino moiety at the 2-position of the core structure. The most potent compound was 2-(2,4-dimethoxyphenyl)imino-5((5(4-carboxaminophenyl)furan-2-yl)methylene)thiazolidin-4-one (19f, IC50 = 0.94 μM), which represents a synergic effect of the two virtual hit compounds against IKK2. We also identified compounds showing inhibitory activities against interleukin (IL)-17, CCK-8, and tumor necrosis factor-alpha (TNF-α), which are NF-κB-dependent pro-inflammatory cytokine mediators.

Structure-activity relationships of novel anti-malarial agents. Part 7: N-(3-benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic acid amides with polar moieties

In a previous report, we have provided evidence that novel anti-malarial compounds based on 2,5-diaminobenzophenone farnesyltransferase inhibitors might benefit from the presence of a polar moiety at the para position of the terminal phenyl of the arylfur